Abstract
Recent studies have demonstrated that the cellular tumour antigen p53 (ref. 1) can complement activated ras genes in the transformation of rat fibroblasts, suggesting that the gene encoding p53 may act as an oncogene2,3. Here, by using in situ chromosomal hybridization4,5, we have mapped the p53 gene to human chromosome 17, at bands 17q21–q22, the region containing one of the breakpoints in the translocation t(15;17) (q22;q21) associated with acute promyelocytic leukaemia (APL)6,7. Hybridization of p53 and erb-A (17qll-ql2) probes to malignant cells from three APL patients indicated that the p53 gene is translocated to chromosome 15 (15q+), whereas erb-A remains on chromosome 17. Analysis of variant translocations demonstrates that the 15q+ chromosome contains the conserved junction8, suggesting a role for p53 in the pathogenesis of APL. However, rearrangements of the p53 gene were not detected on Southern blotting of DNA from leukaemic cells of four APL patients with t(15;17).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Klein, G. (ed.) Advances in Viral Oncology Vol. 2 (Raven, New York, 1982).
Eliyahu, D., Raz, A., Gruss, P., Givol, D. & Oren, M. Nature 312, 646–649 (1984).
Parada, L. F., Land, H., Weinberg, R. A., Wolf, D. & Rotter, V. Nature 312, 649–651 (1984).
Harper, M. E. & Saunders, G. F. Chromosoma 83, 431–439 (1981).
Le Beau, M. M., Westbrook, C. A., Diaz, M. O. & Rowley, J. D. Nature 312, 70–71 (1984).
Rowley, J. D. et al. Int. J. Cancer 20, 869–872 (1977).
Larson, R. A. et al. Am. J. Med. 76, 827–841 (1984).
Rowley, J. D. Science 216, 749–751 (1982).
Zakut-Houri, R. et al. Nature 306, 594–597 (1983).
Mitelman, F. Cytogenet. Cell Genet. 36, 1–516 (1983).
Dayton, A. I. et al. Proc. natn. Acad. Sci. U.S.A. 81, 4495–4499 (1984).
Sheer, D. et al. Proc. natn. Acad. Sci. U.S.A. 80, 5007–5011 (1983).
Sheer, D. et al. Ann. hum. Genet. (in the press).
Matlashewski, G. et al. EMBO J. 3, 3257–3262 (1984).
Wolf, D. & Rotter, V. Proc. natn. Acad. Sci. U.S.A. 82, 790–794 (1984).
Heisterkamp, N. et al. Nature 306, 239–242 (1983).
Croce, C. M. et al. Proc. natn. Acad. Sci. U.S.A. 80, 6922–6926 (1983).
Erikson, J. et al. Proc. natn. Acad. Sci. U.S.A. 80, 7581–7585 (1983).
Groffen, J. et al. Cell 36, 93–99 (1984).
Bernstein, R., Mendelow, B., Morcom, G. & Bezwoda, W. Br. J. Haemal. 46, 311–314 (1980).
Ohyashiki, K. et al. Cancer Genet. Cytogenet. 14, 247–255 (1985).
Yamada, K. et al. Cancer Genet. Cytogenet. 9, 93–99 (1983).
Van den Berghe, H. et al. Cancer 43, 558–562 (1979).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Le Beau, M., Westbrook, C., Diaz, M. et al. Translocation of the p53 gene in t(15;17) in acute promyelocytic leukaemia. Nature 316, 826–828 (1985). https://doi.org/10.1038/316826a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/316826a0
This article is cited by
-
The p53 family: guardians of maternal reproduction
Nature Reviews Molecular Cell Biology (2011)
-
Mouse chromosome 11
Mammalian Genome (1991)
-
The physical map ofMus musculus chromosome 11 reveals evolutionary relationship with different syntenic groups of genes inHomo sapiens
Journal of Molecular Evolution (1987)
-
Localization of gene for human p53 tumour antigen to band 17p13
Nature (1986)
-
Human p53 gene localized to short arm of chromosome 17
Nature (1986)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
