A viral enhancer element specifically active in human haematopoietic cells

Abstract

One particular class of DNA regulatory elements, the enhancers or activators, can, relatively independently of distance and orientation, dramatically increase the transcriptional activity of homologous and heterologous promoters located in cis (see refs 1–3 for reviews, also refs 4–6). Sequence differences between various heterologous enhancers7,8 may explain their apparent host-and/or tissue-specific action9–15. Furthermore, differences in the transcriptional control elements may contribute to viral tropism. At least for murine leukaemia virus isolates, thymotropism and leukaemogenicity have been attributed to alterations within the viral long terminal repeat15–17, which harbours their enhancers and other transcriptional control elements. We report here the identification of a viral enhancer element possessing a very restricted tissue range. The enhancer is active in all human cells of the haematopoetic system tested, but not in cells of fibroblast or epithelial origin.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Khoury, G. & Gruss, P. Cell 33, 313–314 (1983).

    CAS  Article  Google Scholar 

  2. 2

    Gruss, P. DNA 2, 50 (1984).

    Google Scholar 

  3. 3

    Gluzman, Y. & Shenk, T. (eds) Current Communications in Molecular Biology (Cold Spring Harbor Laboratory, New York, w983).

  4. 4

    Banerji, J., Rusconi, S. & Schaffner, W. Cell 27, 299–308 (1981).

    CAS  Article  Google Scholar 

  5. 5

    Moreau, P. et al. Nucleic Acids Res. 9, 6047–6068 (1981).

    ADS  CAS  Article  Google Scholar 

  6. 6

    Wasylik, B., Wasylyk, C., Augereau, P. & Chambon, P. Cell 32, 503–514 (1983).

    Article  Google Scholar 

  7. 7

    Weiher, H., König, M. & Gruss, P. Science 219, 626–631 (1983).

    ADS  CAS  Article  Google Scholar 

  8. 8

    Hen, R., Borrelli, E., Sassone-Corsi, P. & Chambon, P. Nucleic Acids Res. 11, 8747–8760 (1983).

    CAS  Article  Google Scholar 

  9. 9

    Laimins, L., Khoury, G., Gorman, C., Howard, B. H. & Gruss, P. Proc. natn. Acad. Sci. U.S.A. 79, 6453–6457 (1982).

    ADS  CAS  Article  Google Scholar 

  10. 10

    Banerji, J., Olson, L. & Schaffner, W. Cell 33, 729–740 (1983).

    CAS  Article  Google Scholar 

  11. 11

    De Villiers, J., Olson, L., Tyndall, C. & Schaffner, W. Nucleic Acids Res. 10, 7965–7976 (1982).

    CAS  Article  Google Scholar 

  12. 12

    Gillies, S. D., Morrison, S. L., Oi, V. T. & Tonegawa, S. Cell 33, 717–728 (1983).

    CAS  Article  Google Scholar 

  13. 13

    Queen, C. & Baltimore, D. Cell 33, 741–748 (1983).

    CAS  Article  Google Scholar 

  14. 14

    Picard, D. & Schaffner, W. Nature 307, 80–82 (1984).

    ADS  CAS  Article  Google Scholar 

  15. 15

    Lenz, J. et al. Nature 308, 467–470 (1984).

    ADS  CAS  Article  Google Scholar 

  16. 16

    De Groseillers, L., Rassart, E. & Jolicoeur, P. Proc. natn. Acad. Sci. U.S.A. 80, 4203–4207 (1983).

    ADS  Article  Google Scholar 

  17. 17

    Celander, D. & Haseltine, W. A. Nature 312, 159–162 (1984).

    ADS  CAS  Article  Google Scholar 

  18. 18

    Zur Hausen, H. & Gissmann, L. Med. Microbiol. Immun. 167, 137–153 (1979).

    CAS  Article  Google Scholar 

  19. 19

    Zur Hausen, H., Gissmann, L., Minecheva, A. & Böcker, J. F. in Viruses in Naturally Occurring Cancers Vol. 7a (eds Essex, M., Todaro, G. & zur Hausen, H.) 365–373 (Cold Spring Harbor Laboratory, New York, 1980).

    Google Scholar 

  20. 20

    Brade, L., Vogl, W., Gissmann, L. & zur Hausen, H. Virology 114, 228–235 (1981).

    CAS  Article  Google Scholar 

  21. 21

    Takemoto, K. K., Furuno, A., Kato, K. & Yoshiike, K. Virology 42, 502–509 (1982).

    CAS  Google Scholar 

  22. 22

    Pawlita, M., Clad, A. & zur Hausen, H. Virology (in the press).

  23. 23

    Tooze, J. (ed.) DNA Tumor Viruses (Cold Spring Harbor Laboratory, New York, 1983).

  24. 24

    De Villiers, J. & Schaffner, W. Nucleic Acids Res. 9, 6251–6264 (1981).

    CAS  Article  Google Scholar 

  25. 25

    Rosenthal, N., Kress, M., Gruss, P. & Khoury, G. Science 222, 749–755 (1983).

    ADS  CAS  Article  Google Scholar 

  26. 26

    Gruss, P., Dhar, R. & Khoury, G. Proc. natn. Acad. Sci. U.S.A. 78, 943–947 (1981).

    ADS  CAS  Article  Google Scholar 

  27. 27

    Fromm, M. & Berg, P. J. molec. appl. Genet. 1, 457–481 (1982).

    CAS  Google Scholar 

  28. 28

    Kenney, S., Natarajan, V., Strike, D., Khoury, G. & Salzman, N. P. Science 226, 1337 (1984).

    ADS  CAS  Article  Google Scholar 

  29. 29

    Lusky, M., Berg, L., Weiher, H. & Botchan, M. Molec. cell. Biol. 3, 1108–1122 (1983).

    CAS  Article  Google Scholar 

  30. 30

    Gorman, C. M., Moffat, L. F. & Howard, B. H. Molec. cell. Biol. 2, 1044–1051 (1982).

    CAS  Article  Google Scholar 

  31. 31

    Maniatis, T., Fritsch, E. F. & Sambrook, J. Molecular Cloning, 353–354 (Cold Spring Harbor Laboratory, New York, 1982).

    Google Scholar 

  32. 32

    Lusky, M. & Botchan, M. Nature 293, 79–81 (1981).

    ADS  CAS  Article  Google Scholar 

  33. 33

    Kimura, G. & Dulbecco, R. Virology 49, 394–403 (1972).

    CAS  Article  Google Scholar 

  34. 34

    McCutchan, J. H. & Pagano, J. S. J. natn. Cancer Inst. 41, 351 (1965).

    Google Scholar 

  35. 35

    Klein, G., Giovanella, B., Westman, A., Stehlin, J. S. & Munford, D. Intervirology 5, 319–334 (1975).

    CAS  Article  Google Scholar 

  36. 36

    Minowada, J., Ohnuma, T. & Moore, G. E. J. natn. Cancer Inst. 49, 891–895 (1972).

    CAS  Google Scholar 

  37. 37

    Kearney, J. F., Radbruch, A., Liesegang, B. & Rajewski, K. J. Immun. 123, 1548–1550 (1979).

    CAS  Google Scholar 

  38. 38

    Takemoto, K. K. & Tadahito, K. J. Virol. 50, 100–105 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  39. 39

    Green, M. R., Treisman, R. & Maniatis, T. Cell 35, 137–148 (1983).

    CAS  Article  Google Scholar 

  40. 40

    Schöler, H. R. & Gruss, P. Cell 36, 403–411 (1984).

    Article  Google Scholar 

  41. 41

    Mercola, M., Goverman, J., Mirell, C. & Calame, K. Science 227, 266–270 (1985).

    ADS  CAS  Article  Google Scholar 

  42. 42

    Ephrussi, A., Church, G. M., Tonegawa, S. & Gilbert, W. Science 227, 134–139 (1985).

    ADS  CAS  Article  Google Scholar 

  43. 43

    Ziegler, A., Uchanska-Zielger, B., Zeuthen, J. & Wernet, P. Somatic Cell Genet. 8, 775–789 (1982).

    CAS  Article  Google Scholar 

  44. 44

    Edwards, P. A. W. Biochem. J. 200, 1–10 (1981).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Mosthaf, L., Pawlita, M. & Gruss, P. A viral enhancer element specifically active in human haematopoietic cells. Nature 315, 597–600 (1985). https://doi.org/10.1038/315597a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.