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Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

Nature volume 315, pages 550–554 (1985)Cite this article

Abstract

Human chronic myelogenous leukaemia is characterized by a reciprocal translocation between chromosomes 9 and 22 resulting in an abbreviated form of chromosome 22 and the transfer of the abl cellular oncogene from chromosome 9 into the bcr gene of chromosome 22. Characterization of an 8-kilobase RNA specific to chronic myelogenous leukaemia shows it to be a fused transcript of the two genes. The fused protein that would be produced is probably involved in the malignant process.

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Author information

Author notes

  1. Robert P. Gale: Department of Medicine (Hematology and Oncology), UCLA School of Medicine, Los Angeles, California 90024, USA

Authors and Affiliations

  1. Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, 76100, Israel

    Emma Shtivelman, Batia Lifshitz, Robert P. Gale & Eli Canaani

Authors
  1. Emma Shtivelman
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  2. Batia Lifshitz
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  3. Robert P. Gale
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  4. Eli Canaani
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Shtivelman, E., Lifshitz, B., Gale, R. et al. Fused transcript of abl and bcr genes in chronic myelogenous leukaemia. Nature 315, 550–554 (1985). https://doi.org/10.1038/315550a0

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