The basic gene defect in the autosomal recessive disorder cystic fibrosis has not been identified, and no firm linkage of the disorder to any other marker has been reported. However, a serum protein abnormality present in unaffected heterozygotes as well as in affected homozygotes has been described1, and immunological quantitation of this protein, termed cystic fibrosis antigen, allows the three genotypes to be distinguished2,3. We show here that an immunologically indistinguishable protein is present at high concentrations in granulocytes from normal and cystic fibrosis individuals as well as in myeloid leukaemia cells. Somatic cell hybrids between the mouse myeloid stem-cell line WEHI-TG and myeloid leukaemia cells express cystic fibrosis antigen only when human chromosome 1 is present.
Subscribe to Journal
Get full journal access for 1 year
only $3.90 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Wilson, G. B., Fudenberg, H. H. & Jahn, T. L. Pediat. Res. 9, 635–640 (1975).
Manson, J. C. & Brock, D. J. H. Lancet i, 330–331 (1980).
Bullock, S., Hayward, C., Manson, J. C., Brock, D. J. H. & Raeburn, J. A. Clin. Genet. 21, 336–341 (1982).
Romeo, G. in Cystic Fibrosis: Horizons (ed. Lawson, D.) 155–164 (Wiley, Chichester, 1984).
Talamo, R. C., Rosenstein, B. J. & Berninger, R. W. in The Metabolie Basis of Inherited Disease (eds Stanbury, J. B., Wyngaarden, J. B., Frederickson, D. S., Goldstein, J. L. & Brown, M. S.) 1889–1917 (McGraw-Hill, New York, 1983).
Denning, C. R. et al. Pediatrics 66, 752–757 (1980).
van Heyningen, V. Nature 311, 104–105 (1984).
Nevin, G. B., Nevin, N. C., Redmond, A. O., Young, I. R. & Tully, G. W. Hum. Genet. 56, 387–389 (1981).
Brock, D. J. H., Hayward, C. & Super, M. Hum. Genet. 60, 30–31 (1982).
Grataroli, R., Guy-Crotte, O., Galabert, C. & Figarella, C. Pediat. Res. 18, 130–133 (1984).
Geurts van Kessel, A. H. M., Tetteroo, P. A. T., von dem Borne, A. E. G., Hagemeijer, A. & Bootsma, D. Proc. natn. Acad. Sci. U.S.A. 80, 3748–3752 (1983).
Conod, E. J., Conover, J. H. & Hirschhorn, K. Pediat. Res. 9, 724–729 (1975).
Littlefield, J. W. Science 145, 709–710 (1964).
Gallimore, P. H. & Richardson, C. R. Chromosoma 41, 259–263 (1973).
Bobrow, M. & Cross, J. Nature 251, 77–79 (1971).
About this article
Cite this article
van Heyningen, V., Hayward, C., Fletcher, J. et al. Tissue localization and chromosomal assignment of a serum protein that tracks the cystic fibrosis gene. Nature 315, 513–515 (1985). https://doi.org/10.1038/315513a0
Next-generation technologies for spatial proteomics: Integrating ultra-high speed MALDI-TOF and high mass resolution MALDI FTICR imaging mass spectrometry for protein analysis
Oxidation of calprotectin by hypochlorous acid prevents chelation of essential metal ions and allows bacterial growth: Relevance to infections in cystic fibrosis
Free Radical Biology and Medicine (2015)
Two Proteins Modulating Transendothelial Migration of Leukocytes Recognize Novel Carboxylated Glycans on Endothelial Cells
The Journal of Immunology (2001)
High Level Expression and Dimer Characterization of the S100 EF-hand Proteins, Migration Inhibitory Factor-related Proteins 8 and 14
Journal of Biological Chemistry (1998)
Molecular Pathology (1997)