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Hypervariable ‘minisatellite’ regions in human DNA

Naturevolume 314pages6773 (1985) | Download Citation

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Abstract

The human genome contains many dispersed tandem-repetitive ‘minisatellite’ regions detected via a shared 10–15-base pair ‘core’ sequence similar to the generalized recombination signal (χ) of Escherichia coli. Many minisatellites are highly polymorphic due to allelic variation in repeat copy number in the minisatellite. A probe based on a tandem-repeat of the core sequence can detect many highly variable loci simultaneously and can provide an individual-specific DNA ‘fingerprint’ of general use in human genetic analysis.

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Affiliations

  1. Department of Genetics, University of Leicester, University Road, Leicester, LE1 7RH, UK

    • Alec J. Jeffreys
    •  & Victoria Wilson
  2. MRC Molecular Haematology Unit, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK

    • Swee Lay Thein

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https://doi.org/10.1038/314067a0

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