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Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

Abstract

Exposure of quiescent mouse fibroblasts to platelet-derived growth factor induces mRNA from the c-fos proto-oncogene within 10 min followed by synthesis of nuclear c-fos proteins. These are amongst the earliest described nuclear events that follow a mitogenic stimulus.

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Kruijer, W., Cooper, J., Hunter, T. et al. Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein. Nature 312, 711–716 (1984). https://doi.org/10.1038/312711a0

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