Abstract
A series of rat neuro/glioblastomas all contain the same transforming gene (neu) which induces synthesis of a tumour antigen of relative molecular mass (Mr) 185,000 (p185). The neu oncogene bears homology to erb-B and the tumour antigen, p185, is serologically related to the epidermal growth factor (EGF) receptor. The two proteins, EGF receptor and p185 appear to be distinct, as they coexist in nontransformed Rat-1 cells.
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References
Bishop, J. M. A. Rev. Biochem. 52, 301–354 (1983).
Land, H., Parada, L. & Weinberg, R. A. Science 222, 771–778 (1983).
Schubert, D. et al. Nature 249, 224 (1974).
Shih, C., Padhy, L. C., Murray, M. & Weinberg, R. A. Nature 290, 261–264 (1981).
Padhy, L. D., Shih, C., Cowing, D., Finkelstein, R & Weinberg, R. A. Cell 28, 865–871 (1982).
Downward, J. et al. Nature 307, 521–527 (1984).
Haigler, H. J., Ash, J., Singer, J. and Cohen, S. Proc. natn. Acad. Sci. U.S.A. 75, 3317–3321 (1978).
Hunter, T. A. & Cooper, J. A. Cell 24, 741–752 (1981).
Cohen, S. H., Ushiro, C., Stoscheck, C. & Chinkers, M. J. biol. Chem. 257, 1523–1531 (1982).
Decker, S. J. Molec. cell. Biol. 4, 4 (1984).
Drebin, J. A., Stern, D. F., Link, V. C., Weinberg, R. A. & Greene, M. I. Nature 312, 545–548 (1984).
Shih, C. & Weinberg, R. A. Cell 29, 161–169 (1982).
Carpenter, G., King, L. E. & Cohen, S. J. biol. Chem. 254, 4884–4891 (1979).
Fabricant, R., DeLarco, J. E. & Todaro, G. J. Proc. natn. Acad. Sci. U.S.A. 74, 565–569 (1977).
Decker, S. Archs Biochem. Biophys. 228, 621–626 (1984).
Sukumar, S., Notaris, V., Martin-Zanca, D. & Barbacid, M. Nature 306, 658–661 (1983).
Balmain, A. & Praznell, I. Nature 303, 72–74 (1983).
Rajewsky, M. F. in Recent Results in Cancer Research (ed. Nass, G.) 763–766 (Springer, New York, 1983).
Rajewsky, M. F. et al. in Origins of Human Cancer (eds Hiatt, H, Watson, J. D. & Winsten, J. A.) 709–726 (Cold Spring Harbor Laboratory, New York, 1972).
Cowley, J., Gustason, B., Smith, J., Hendler, F. & Ozanne, B. in The Cancer Cell (eds Levine, A. J., Topp, W., Vande Woude, G. & Watson, J. D.) 9 (Cold Spring Harbor Laboratory, New York, 1983).
Liebermann, T. A. et al. Cancer Res. 44, 753–760 (1984).
Vennstrom, B., Fanshier, L., Moscovici, C. & Bishop, J. M. J. Virol. 36, 575–585 (1980).
Sefton, B. M., Beemon, K. & Hunter, T. J. Virol. 28, 957–971 (1978).
Skinner, M. & Griswold, M. P. Biochem. J. 209, 281–284 (1984).
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Schechter, A., Stern, D., Vaidyanathan, L. et al. The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen. Nature 312, 513–516 (1984). https://doi.org/10.1038/312513a0
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DOI: https://doi.org/10.1038/312513a0
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