Abstract
In addition to the two previously identified genes rearranged and expressed in a cytotoxic T-lymphocyte clone, we have identified a third gene that is also rearranged and expressed in the same clone. This new gene shows clonal diversity, codes for a polypeptide chain that contains immunoglobulin-like variable and constant domains, carries potential N-glycosylation sites and is a particularly attractive candidate for the gene that encodes the α-subunit of the heterodimeric antigen receptor of this T-cell clone.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Jensenius, J. C. & Williams, A. F. Nature 300, 583–588 (1982).
Kindred, B. & Shreffler, D. C. J. Immun. 109, 940–943 (1972).
Katz, D. H., Hamaoka, T., Dorf, E. D., Maurer, P. H. & Benacerraf, B. J. exp. Med. 138, 734–739 (1973).
Zinkernagel, R. M. & Doherty, P. C. Nature 248, 701–702 (1974).
Allison, J. P., McIntyre, B. W. & Bloch, D. J. Immun. 129, 2293–2300 (1982).
Meuer, S. C. et al. J. exp. Med. 157, 705–719 (1983).
Haskins, K. et al. J. exp. Med. 157, 1149–1169 (1983).
Acuto, O. et al. Cell 34, 717–726 (1983).
McIntyre, B. W. & Allison, J. P. Cell 34, 739–746 (1983).
Kappler, J. et al. Cell 35, 295–302 (1983).
Yanagi, Y. et al. Nature 308, 145–149 (1984).
Hedrick, S. M., Nielsen, E. A., Kavaler, J., Cohen, D. I. & Davis, M. M. Nature 308, 153–158 (1984).
Saito, H. et al. Nature 309, 757–762 (1984).
Acuto, O. et al. Proc. natn. Acad. Sci. U.S.A. 81, 3851–3855 (1984).
Chien, Y., Gascoigne, N. R. J., Kavaler, J., Lee, N. E. & Davis, M. M. Nature 309, 322–326 (1984).
Gascoigne, N. R. J., Chien, Y., Becker, D. M., Kavaler, J. & Davis, M. M. Nature 310, 387–391 (1984).
Siu, G. et al. Cell 37, 393–401 (1984).
Malissen, M. et al. Cell 37, 1101–1110 (1984).
Kavaler, J., Davis, M. M. & Chien, Y. Nature 310, 421–423 (1984).
Siu, G. et al. Nature 311, 344–350 (1984).
Kranz, D. M., Sherman, D. H., Sitkovsky, M. V., Pasternack, M. S. & Eisen, H. N. Proc. natn. Acad. Sci. U.S.A. 81, 573–577 (1984).
Southern, E. J. molec. Biol. 98, 503–517 (1975).
Thomas, P. S. Meth. Enzym. 100, 255–266 (1983).
Maxam, A. M. & Gilbert, W. Meth. Enzym. 65, 499–560 (1980).
Blobel, G. & Dobberstein, B. J. Cell Biol. 67, 835–851 (1975).
Kabat, E. A., Wu, T. T., Bilofsky, H., Reid-Miller, M. & Perry, H. Sequences of Proteins of Immunological Interest (NIH, Bethesda, 1983).
Von Boehmer, H., Haas, W. & Jerne, N. K. Proc. natn. Acad. Sci. U.S.A. 75, 2439–2442 (1978).
Blanden, R. V. & Ada, G. L. Scand. J. Immun. 7, 181–190 (1978).
Langman, R. E. Rev. Physiol. Biochem. Pharmac. 81, 1–37 (1978).
Zinkernagel, R. M. et al. J. exp. Med. 147, 882–896 (1978).
Cohn, M. & Epstein, R. E. Cell. Immun. 39, 125–153 (1978).
Janeway, C. A. Jr, Wigzell, H. & Binz, H. Scand. J. Immun. 5, 993–1001 (1976).
Matzinger, P. Nature 292, 497–501 (1981).
Hunig, T. R. & Bevan, M. J. J. exp. Med. 155, 111–125 (1982).
Hedrick, S. M. et al. Cell 30, 141–152 (1982).
Kappler, J. W., Skidmore, B., White, J. & Marrack, P. J. exp. Med. 153, 1198–1214 (1981).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Saito, H., Kranz, D., Takagaki, Y. et al. A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes. Nature 312, 36–40 (1984). https://doi.org/10.1038/312036a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/312036a0
This article is cited by
-
Identification of the transgenic integration site in 2C T cell receptor transgenic mice
Transgenic Research (2018)
-
Quantitative Peripheral Blood Perturbations of γδ T Cells in Human Disease and Their Clinical Implications
Clinical Reviews in Allergy & Immunology (2014)
-
Defining the nature of human γδ T cells: a biographical sketch of the highly empathetic
Cellular & Molecular Immunology (2013)
-
Germline genomic structure of the B10.A mouseTcra-V2 gene subfamily
Immunogenetics (1996)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.