Abstract
In rats, striatal neuronal destruction by so-called excitotoxic amino acids, kainic acid or ibotenic acid (IA) produce neuropathological and neurochemical changes in the basal ganglia1–4 which resemble those seen in patients with Huntington's chorea5,6. Such lesioned animals show a behavioural syndrome which is reminiscent of the cardinal symptoms of the disease7–12, accompanied by a substantial increase in local cerebral metabolic activity in several striatal target structures within the extrapyramidal motor system13–15. The study was designed to explore the potential of grafted fetal striatal neurones implanted into the IA-lesioned striatum to compensate for the structural, neurochemical, metabolic and behavioural defects of IA-lesioned rats. Extending previous studies16,17, we report here that such striatal implants can significantly ameliorate the lesion-induced locomotor hyperactivity and at least partly normalize the metabolic hyperactivity in the extrapyramidal neuronal system.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Coyle, J. T. & Schwarcz, R. Nature 263, 244–246 (1976).
McGeer, E. G. & McGeer, P. L. Nature 263, 517–519 (1976).
Schwarcz, R. & Coyle, J. T. Brain Res. 127, 235–249 (1977).
Schwarcz, R. et al. Expl Brain Res. 37, 199–216 (1979).
Bruyn, G. W. Prog. Brain Res. 55, 445–464 (1982).
Bird, E. D. A. Rev. Pharmac. Tox. 20, 533–551 (1980).
Mason, S. T. & Fibiger, H. C. Brain Res. 155, 313–329 (1978).
Mason, S. T. & Fibiger, H. C. Neuropharmacology 18, 403–407 (1979).
Sanberg, P. R. & Fibiger, H. C. Expl Neurol. 66, 444–466 (1979).
Dunnett, S. B. & Iversen, S. D. Behav. Brain Res. 2, 189–209 (1981).
Dunnett, S. B. & Iversen, S. D. Behav. Brain Res. 1, 497–506 (1980).
Pisa, M., Sanberg, P. R. & Fibiger, H. C. Expl Neurol. 74, 633–653 (1981).
Kimura, H., McGeer, E. G. & McGeer, P. L. J. neural Transmission Suppl. 16, 103–109 (1980).
Wooten, G. F. & Collins, R. C. Brain Res. 201, 173–184 (1980).
Kelly, P. A. T., Graham, D. I. & McCulloch, J. Brain Res. 233, 157–172 (1982).
Schmidt, R. H., Björklund, A. & Stenevi, U. Brain Res. 218, 347–356 (1981).
Deckel, A. W., Robinson, R. G., Coyle, J. T. & Sanberg, P. R. Eur. J. Pharmac. 93, 287–288 (1983).
Sokoloff, L. et al. J. Neurochem. 28, 897–916 (1977).
Fonnum, F., Storm-Mathisen, J. & Walberg, F. Brain Res. 20, 259–275 (1970).
Krammer, E. B. Brain Res. 196, 209–219 (1980).
Dawbarn, D. et al. Brain Res. (submitted).
Glick, S. D. & Cox, R. D. Brain Res. 150, 149–161 (1978).
Björklund, A., Dunnett, S. B., Stenevi, U., Lewis, M. E. & Iversen, S. D. Brain Res. 199, 307–333 (1980).
Freed, W. J. et al. Ann. Neurol. 8, 510–519 (1980).
Björklund, A., Stenevi, U., Dunnett, S. B. & Iversen, S. D. Nature 289, 497–499 (1981).
Freed, W. J. et al. Nature 292, 351–352 (1981).
Björklund, A., Stenevi, U., Schmidt, R. H., Dunnett, S. B. & Gage, F. H. Acta physiol. scand. Suppl. 522, 1–8 (1983).
Dunnett, S. B., Björklund, A. & Stenevi, U. Trends Neurosci. 6, 266–270 (1983).
Kelly, P. A. T. & McCulloch, J. Br. J. Pharmac. 76, 290 (1982).
Mogenson, G. J. & Nielsen, M. A. Brain Res. Bull. 11, 309–314 (1983).
Schwartz, W. J. & Sharp, S. R. J. comp. Neurol. 177, 335–360 (1978).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Isacson, O., Brundin, P., Kelly, P. et al. Functional neuronal replacement by grafted striatal neurones in the ibotenic acid-lesioned rat striatum. Nature 311, 458–460 (1984). https://doi.org/10.1038/311458a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/311458a0
This article is cited by
-
Facile consecutive three-component synthesis of 3,5-disubstituted isoxazoles
Chemistry of Heterocyclic Compounds (2017)
-
Fetal striatal transplants restore electrophysiological sensitivity to dopamine in the lesioned striatum of rats with experimental Huntington's disease
Journal of Biomedical Science (2002)
-
Gene therapy in the CNS
Gene Therapy (2000)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.