Abstract
Transfer of mouse or human c-fos proto-oncogenes into F9 teratocarcinoma stem cells results in expression of c-fos mRNA and protein. This is accompanied by the appearance of morphologically altered cells which express several specific markers characteristic of differentiated cells, suggesting that c-fos plays a role in cellular differentiation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Waterfield, M. D. et al. Nature 304, 35–39 (1983).
Doolittle, R. F. et al. Science 221, 275–277 (1983).
Downward, J. et al. Nature 307, 521–527 (1984).
Kelly, K., Cochran, B. H., Stiles, C. D. & Leder, P. Cell 35, 603–610 (1983).
Campisi, J., Gray, H. E., Pardee, A. B., Dean, M. & Sonenshein, G. E. Cell 36, 241–247 (1984).
Westin, E. H. et al. Proc. natn. Acad. Sci. U.S.A. 79, 2194–2198.
Müller, R., Slamon, D. J., Tremblay, J. M., Cline, M. J. & Verma, I. M. Nature 299, 640–644 (1982).
Müller, R., Verma, I. M. & Adamson, E. D. EMBO J. 2, 679–684 (1983).
Müller, R., Tremblay, J. M., Adamson, E. D. & Verma, I. M. Nature 304, 454–456 (1983).
Müller, R., Müller, D. & Guilbert, L. EMBO J. 3, 1887–1890 (1984).
Bernstine, E. G., Hooper, M. L., Grandchamp, S. & Ephrussi, B. Proc. natn. Acad. Sci. U.S.A. 70, 3899–3903 (1973).
Mintz, B. & Fleischman, R. A. Adv. Cancer Res. 34, 221–278 (1981).
Wagner, E. F., Rüther, U. & Stewart, C. L. in The Impact of Gene Transfer Techniques in Eucaryotic Cell Biology (Springer, Berlin, in the press).
Strickland, S. & Mahdavi, V. Cell 15, 393–403 (1978).
Hogan, B. L. M., Taylor, A. & Adamson, E. Nature 291, 235–237 (1981).
Liesi, P., Rechardt, L. & Wartiovaara, J. Nature 306, 265–267 (1983).
Müller, R. Cold Spring Harb. Conf. Cell Prolif, 10, 451–468 (1983).
van Straaten, F., Müller, R., Curran, T., van Beveren, C. & Verma, I. M. Proc. natn. Acad. Sci. U.S.A. 80, 3183–3187 (1983).
Van Beveren, C., van Straaten, F., Curran, T., Müller, R. & Verma, I. M. Cell 32, 1241–1255 (1983).
Southern, P. J. & Berg, P. J. molec. appl. Genet. 1, 327–341 (1982).
Southern, E. M. J. molec. Biol. 98, 503–517 (1975).
Curran, T. & Teich, N. M. J. Virol. 42, 114–122 (1982).
Curran, T., Miller, A. D., Zokas, F. L. & Verma, I. M. Cell 36, 259–268 (1984).
Miller, A. D., Curran, T. & Verma, I. M. Cell 36, 51–60 (1984).
Boller, K. & Kemler, R. Cold Spring Harb. Conf. Cell Prolif. 10, 39–49 (1983).
Kahan, B. & Adamson, E. D. Cold Spring Harb. Conf. Cell Prolif. 10, 131–141 (1983).
Adamson, E. D., Gaunt, S. J. & Graham, C. F. Cell 17, 469–476 (1979).
Waneck, G. L. & Rosenberg, N. Cell 26, 79–89 (1981).
Witte, O. N. Curr. Topics Microbiol. Immun. 103, 127–146 (1983).
Rassoulzadegan, M. et al. Proc. natn. Acad. Sci. U.S.A. 80, 4354–4358 (1983).
Houweling, A., van der Elsen, P. & van der Eb., A. Virology 105, 537–550 (1980).
Karin, M. et al. Nature 308, 513–519 (1984).
Graham, F. L. & van der Eb, A. J. Virology 53, 456–467 (1973).
Wagner, E. F. & Mintz, B. Molec. cell. Biol., 2, 190–198 (1982).
Müller, R. et al. Molec. cell Biol. 3, 1062–1069 (1983).
Curran, T., Peters, G., van Beveren, C., Teich, N. M. & Verma, I. M. J. Virol. 44, 674–682 (1982).
Lehrach, H., Diamond, D., Wozney, J. M. & Boedtcher, H. Biochemistry 16, 4743–4751 (1977).
Adamson, E.D. & Grover, A. Cold Spring Harb. Conf. Cell Prolif. 10, 69–81 (1983).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Müller, R., Wagner, E. Differentiation of F9 teratocarcinoma stem cells after transfer of c-fos proto-oncogenes. Nature 311, 438–442 (1984). https://doi.org/10.1038/311438a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/311438a0
This article is cited by
-
Transcription factor AP‐1, and the role of Fra‐2
Immunology & Cell Biology (1996)
-
Expression of c-Fos in subcutaneous adipose tissue of the fetal pig
Molecular and Cellular Biochemistry (1996)
-
Transcription factor regulation of epidermal keratinocyte gene expression
Molecular Biology Reports (1996)
-
Oncogenic regulation and function of keratins 8 and 18
Cancer and Metastasis Review (1996)
-
DNA synthesis is dissociated from the immediate-early gene response in the post-ischemic kidney
Kidney International (1995)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.