Abstract
Class II molecules of the major histocompatibility complex (MHC) are heterodimeric glycoproteins expressed on the surface of antigen-presenting B lymphocytes and macrophages1. The genes encoding the α- and β-chains of the class II heterodimers, AαAβ and EαEβ, have recently been characterized at the molecular level2–5, and certain cloned genes were shown to be functionally expressed after introduction into cells by DNA-mediated gene transfer6,7. One study7 found that a transfected Ebβ gene was expressed in a macrophage cell only after treatment of cells with γ-interferon. DNA sequences associated with transfected Class II MHC genes may therefore have a regulatory role in their cell type-specific expression. We report here the identification of a cell type-specific transcriptional enhancer element associated with the mouse Edβ gene.
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Gillies, S., Folsom, V. & Tonegawa, S. Cell type-specific enhancer element associated with a mouse MHC gene, Eβ. Nature 310, 594–597 (1984). https://doi.org/10.1038/310594a0
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DOI: https://doi.org/10.1038/310594a0
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