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Regional localization of sex-specific Bkm-related sequences on proximal chromosome 17 of mice

Nature volume 310, pages 579–581 (1984)Cite this article

Abstract

Development and fertility in the mouse are known1,2 to be influenced by loci mapped to the T/t complex of chromosome 17. Recent evidence suggests that one or more genes near this region may also be associated with sex determination. Washburn and Eicher3 recently reported partial to complete sex reversal with the Thp deletion on some genetic backgrounds and suggest that this result may be due to a primary sex-determining locus (Tas) that is closely linked to, or a part of, the T locus. Sex-specific, Bkm (banded Krait minor satellite DNA)-related sequences are known to have autosomal as well as heterogametic sex chromosomal copies, but specific regions of autosomal localization have not been described4,5. We now demonstrate the presence of chromosome Y-related DNA sequences on proximal chromosome 17 in Sex-reversed (Sxr) and normal mice using in situ hybridization of mitotic chromosomes with 3H-labelled pCS316 (ref. 4), a probe that shows major hybridization to the proximal portion of the mouse chromosome Y6,7. These data, and those of Washburn and Eicher3, argue for a gene(s) related to sex determination or differentiation within the proximal portion of mouse chromosome 17.

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Authors and Affiliations

  1. Department of Human Genetics, University of Michigan Medical School, Box 015, Ann Arbor, Michigan, 48109–0010, USA

    Karen Kiel-Metzger & Robert P. Erickson

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  1. Karen Kiel-Metzger
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  2. Robert P. Erickson
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Kiel-Metzger, K., Erickson, R. Regional localization of sex-specific Bkm-related sequences on proximal chromosome 17 of mice. Nature 310, 579–581 (1984). https://doi.org/10.1038/310579a0

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