Abstract
Plasmacytoid tumours in mice and Burkitt's lymphomas in humans display characteristic chromosomal translocations involving the c-myc proto-oncogene1,2. Models to explain quantitative changes in c-myc expression have been proposed based on the loss of normal promoters3–9 as a result of translocation. However, alternative explanations10–16, such as somatic mutation14,17,18, are needed to explain altered c-myc expression in the absence of gene breakage. We present here the nucleotide sequence of the normal murine c-myc gene. Comparison of this sequence with that of a translocated c-myc gene from a murine plasmacytoma reveals complete identity of coding sequence. One nucleotide difference was found in the non-coding first exon. This shows that qualitative changes of the c-myc gene product are not required for ontogenesis in murine plasmacytomas. In contrast, mutations are found in coding18 and non-coding14 regions of translocated c-myc genes from Burkitt's lymphomas, suggesting that the mechanisms by which c-myc is activated in plasmacytomas and Burkitt's lymphomas are different.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Klein, G. Cell 32, 311–315 (1983).
Perry, R. P. Cell 33, 647–649 (1983).
Marcu, K. B. et al. Proc. natn. Acad. Sci. U.S.A. 80, 519–523 (1983).
Mushinski, J. F., Bauer, S. R., Potter, M. & Premkumar-Reddy, E. Proc. natn. Acad. Sci. U.S.A. 80, 1073–1077 (1983).
Erikson, J., Ar-Rushdi, A., Orwinga, H. L., Vowell, P. C. & Croce, C. M. Proc. natn. Acad. Sci. U.S.A. 80, 820–824 (1983).
Stanton, L. W., Watt, R. & Marcu, K. B. Nature 303, 401–406 (1983).
Hayday, A. C. et al. Nature 307, 334–340 (1984).
Adams, J., Gerondakis, S., Webb, E., Corcoran, L. M. & Cory, S. Proc. natn. Acad. Sci. U.S.A. 80, 1982–1986 (1983).
Bernard, O., Cory, S., Gerondakis, S., Webb, E. & Adams, J. M. EMBO J 2, 2375–2383 (1983).
Leder, P. et al. Science 222, 765–771 (1983).
Nishikura, K. et al. Proc. natn. Acad. Sci. U.S.A. 80, 4822–4826 (1983).
Croce, C. M. et al. Proc. natn. Acad. Sci. U.S.A. 80, 6922–6926 (1983).
Erikson, J. et al. Proc. natn. Acad. Sci. U.S.A. 80, 7581–7585 (1983).
Taub, R. et al. Cell 36, 339–348 (1984).
Hollis, G. F. et al. Nature 307, 752–755 (1984).
Yang, J. Q. et al. in Current Topics in Microbiology and Immunology (eds Potter, M., Melchers, F. & Weigert, M.) (Springer, New York, in the press).
Hamlyn, P. H. & Rabbits, T. H. Nature 304, 135–139 (1983).
Rabbits, T. H., Hamlyn, P. H. & Baer, R. Nature 306, 760–765 (1983).
Harris, L. J., Land, R. B. & Marcu, K. B. Proc. natn. Acad. Sci. U.S.A. 79, 4175–4179 (1982).
Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A 74, 5463–5467 (1977).
Messing, J., Crea, R. & Seeburg, P. H. Nucleic Acids Res. 9, 309–322 (1981).
Poncz, M., Solowiejczyk, D., Ballantine, M., Schwartz, E. & Surrey, S. Proc. natn. Acad. Sci. U.S.A. 79, 4298–4302 (1982).
Frischauf, A., Garoff, H. & Lebrach, H. Nucleic Acids Res. 8, 5541–5549 (1980).
Stanton, L. W. et al. Proc. natn. Acad. Sci. U.S.A. 81, 829–835 (1984).
Watt, R. et al. Nature 303, 725–728 (1983).
Saito, H., Hayday, A. C., Wiman, K., Hayward, W. S. & Tonegawa, S. Proc. natn. Acad. Sci. U.S.A. 80, 7476–7480 (1983).
Calame, K. et al. Proc. natn. Acad. Sci. U.S.A. 79, 6994–6998 (1982).
Adams, J. M. et al. Proc. natn. Acad. Sci. U.S.A. 79, 6966–6970 (1982).
Neuberger, M. S. & Calabi, F. Nature 305, 240–243 (1983).
Dunnick, W., Shell, B. E. & Dery, C. Proc. natn. Acad. Sci. U.S.A. 80, 7269–7273 (1983).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Stanton, L., Fahrlander, P., Tesser, P. et al. Nucleotide sequence comparison of normal and translocated murine c-myc genes. Nature 310, 423–425 (1984). https://doi.org/10.1038/310423a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/310423a0
This article is cited by
-
The Mad1 transcription factor is a novel target of activin and TGF-β action in keratinocytes: possible role of Mad1 in wound repair and psoriasis
Oncogene (2001)
-
Structure of vertebrate genes: A statistical analysis implicating selection
Journal of Molecular Evolution (1988)
-
Differential expression of myc family genes during murine development
Nature (1986)
-
Deregulated expression of c-myc by murine erythroleukaemia cells prevents differentiation
Nature (1986)
-
Rearrangement and enhanced expression of c-myc in hepatocellular carcinoma of hepatitis virus infected woodchucks
Nature (1986)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.