Abstract
Homoeotic genes in the bithorax and Antennapedia complexes of Drosophila melanogaster appear to specify the developmental fate of segments of the fly. Some of these genes (Ultrabithorax, Antennapedia and fushi tarazu) share homology due to their conservation of a ‘homoeo domain’1,2 consisting of 60 amino acids. Cross-hybridization and cloning experiments show that the homoeo domain is conserved in a frog (Xenopus laevis) gene expressed in early development3 and may also be present in earthworm, beetle, chicken, mouse and human genomes2. The extreme conservation found in the amino acid sequences between the Drosophila and Xenopus domains suggests that the domain has a vital function in the control of early development. Here we report the results of a search made in the Dayhoff sequence bank, which reveals a lesser but apparently significant homology between the homoeo domain and the amino acids coded from parts of the a1 and α2 mating type genes of the yeast Saccharomyces cerevisiae4,5.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
McGinnis, W., Levine, M. S., Hafen, E., Kuroiwa, A. & Gehring, W. J. Nature 308, 428–433 (1984).
McGinnis, W., Garber, R. L., Wirz, J., Kuroiwa, A. & Gehring, W. J. Cell (in the press).
Carrasco, A. E., McGinnis, W., Gehring, W. J. & De Robertis, E. M. Cell (in the press).
Astell, C. R. et al. Cell 27, 15–23 (1981).
Tatchell, K., Nasmyth, K. A., Hall, B. J., Astelle, C. & Smith, M. Cell 27, 25–35 (1981).
Kabsch, W. & Sander, C. Proc. natn. Acad. Sci. U.S.A. 81, 1075–1078 (1984).
Herskowitz, I. & Oshima, Y. in The Molecular Biology of the Yeast Saccharomyces (eds Strathern, J. N., Jones, E. W. & Broach, J. R.) 181–209 (Cold Spring Harbor Laboratory, New York, 1981).
Nasmyth, K. A. A. Rev. Genet. 16, 439–500 (1982).
Matthews, B. W., Ohlendorf, D. H., Anderson, W. F., Fisher, R. G. & Takeda, Y. Cold Spring Harb. Symp. quant. Biol. 47, 427–432 (1982).
Ohlendorf, D. H., Anderson, W. F. & Matthews, B. W. J. molec. Evol. 19, 109–114 (1983).
Miller, A. M. EMBO J. 3, 1061–1065 (1984).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shepherd, J., McGinnis, W., Carrasco, A. et al. Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins. Nature 310, 70–71 (1984). https://doi.org/10.1038/310070a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/310070a0
This article is cited by
-
Genome-wide identification and expression analysis of homeobox genes in Fusarium oxysporum f. sp. lycopersici
Journal of Plant Pathology (2022)
-
The molecular foundations of zygosis
Cellular and Molecular Life Sciences (2020)
-
Hox genes, evo-devo, and the case of the ftz gene
Chromosoma (2016)
-
From fruit flies to fallout: Ed Lewis and his science
Journal of Genetics (2004)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.