Abstract
DNA sequencing shows that the intragenic duplication within the human haptoglobin Hp2 allele was formed by a non-homologous, probably random, crossing-over within different introns of two Hp1genes, probably in an Hp1F/Hp1S heterozygote.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Haptoglobin polymorphisms in Latin American populations
Scientific Reports Open Access 13 August 2020
-
Human gut derived-organoids provide model to study gluten response and effects of microbiota-derived molecules in celiac disease
Scientific Reports Open Access 07 May 2019
-
Haptoglobin phenotype prevalence and cytokine profiles during Plasmodium falciparum infection in Dogon and Fulani ethnic groups living in Mali
Malaria Journal Open Access 25 November 2013
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Smithies, O. Nature 175, 307 (1955).
Smithies, O. & Walker, N. F. Nature 176, 1265–1266 (1955).
Smithies, O. & Walker, N. F. Nature 178, 694–695 (1956).
Connell, G. E., Dixon, G. H. & Smithies, O. Nature 193, 505–506 (1962).
Smithies, O., Connell, G. E. & Dixon, G. H. Am. J. hum. Genet. 14, 14–21 (1962).
Smithies, O., Connell, G. E. & Dixon, G. H. Nature 196, 232–236 (1962).
Nance, W. E. & Smithies, O. Nature 198, 869–870 (1963).
vander Straten, A., Herzog, A., Jacobs, P., Cabezon, T. & Bollen, A. EMBO J. 2, 1003–1007 (1983).
Yang, F., Brune, J. L., Baldwin, W. D., Barnett, D. R. & Bowman, B. H. Proc. natn. Acad. Sci. U.S.A. 80, 5875–5879 (1983).
Raugei, G. et al. Nucleic Acids Res. 11, 5811–5819 (1983).
Barnett, D. R. et al. Protides of the Biological Fluids, 22nd Colloq. (ed. Peelers, H.) 589 (Pergamon, New York, 1975).
Southern, E. M. J. molec. Biol. 98, 503–517 (1975).
Loenen, W. A. M. & Blattner, F. R. Gene 26, 171–179 (1983).
Hohn, B. Meth. Enzym. 68, 299–309 (1979).
Maeda, N., Bliska, J. B. & Smithies, O. Proc. natn. Acad. Sci. U.S.A. 80, 5012–5016 (1983).
Maxam, A. M. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 74, 560–564 (1977).
Black, J. A. & Dixon, G. H. Nature 218, 736–742 (1968).
Nordheim, A. & Rich, A. Proc. natn. Acad. Sci. U.S.A. 80, 1821–1825 (1983).
Slightom, J. L., Blechl, A. E. & Smithies, O. Cell 21, 627–638 (1980).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Maeda, N., Yang, F., Barnett, D. et al. Duplication within the haptoglobin Hp2 gene. Nature 309, 131–135 (1984). https://doi.org/10.1038/309131a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/309131a0
This article is cited by
-
Haptoglobin polymorphisms in Latin American populations
Scientific Reports (2020)
-
Blood-Related Toxicity after Traumatic Brain Injury: Potential Targets for Neuroprotection
Molecular Neurobiology (2020)
-
Human gut derived-organoids provide model to study gluten response and effects of microbiota-derived molecules in celiac disease
Scientific Reports (2019)
-
Recurring exon deletions in the HP (haptoglobin) gene contribute to lower blood cholesterol levels
Nature Genetics (2016)
-
Recurrent mutation at the classical haptoglobin structural polymorphism
Nature Genetics (2016)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.