Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Inhibition of antigen-induced T-cell clone proliferation by antigen-specific antibodies


Attempts to inhibit the recognition of soluble antigens by T lymphocytes using antibodies specific for the antigen in question have been uniformally unsuccessful, in contrast to the observed specific inhibition of antibody generation by B cells1. One exception is the unique situation whereby anti-hapten antisera inhibit the T-cell prolif erative responses observed when hapten-specific T lymphocytes2,3 or clones4 are cultured with hapten-derivatized cells or proteins. The inability to inhibit T-cell functions by antigen-specific antibodies has been interpreted in several ways: (1) T cells possess a different repertoire from B cells; (2) the antibodies tested recognize epitopes present on the native antigen, whereas T cells recognize non-native (processed) structures; (3) the antigenic determinant(s) recognized by T cells on the surface of antigen presenting cells are either not accessible to antibodies, or are present in low amounts3. The development of antigen-specific T-cell clones and monoclonal antibodies both specific for the same antigenic determinants now allows this question to be investigated definitively. Here, we report for the first time the specific inhibition of antigen-induced T-cell clone proliferation by a monoclonal antibody directed against the relevant soluble protein antigen.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others


  1. Uhr, J. & Moeller, G. Adv. Immun. 8, 81–126 (1968).

    Article  CAS  Google Scholar 

  2. Thomas, D. W. & Shevach, E. M. J. Immun. 121, 1145–1151 (1978).

    CAS  PubMed  Google Scholar 

  3. Schevach, E. M., Chan, C. & Clement, L. T. Eur. J. Immun. 12, 819–824 (1982).

    Article  Google Scholar 

  4. Clayberger, C., Dekruyff, R. H., Aisenberg, J. & Cantor, H. J. exp. Med. 157, 1906–1919 (1983).

    Article  CAS  Google Scholar 

  5. Corradin, G., Zubler, R. H. & Engers, H. D. J. Immun. 127, 2442–2446 (1981).

    CAS  PubMed  Google Scholar 

  6. Corradin, G., Juillerat, M. A., Vita, C. & Engers, H. D. Molec. Immun. 20, 763–768 (1983).

    Article  CAS  Google Scholar 

  7. Weiss, A., Brunner, K. T., MacDonald, H. R. & Cerottini, J.-C. J. exp. Med. 152, 1210–1229 (1980).

    Article  CAS  Google Scholar 

  8. Louis, J. A. et al. Immun. Rev. 61, 215–243 (1982).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

Corradin, G., Engers, H. Inhibition of antigen-induced T-cell clone proliferation by antigen-specific antibodies. Nature 308, 547–548 (1984).

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI:

This article is cited by


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing