Abstract
A repetitive DNA sequence has been identified in the Drosophila melanogaster genome that appears to be localized specifically within genes of the bithorax and Antennapedia complexes that are required for correct segmental development. Initially identified in cloned copies of the genes Antennapedia, Ultrabithorax and fushi tarazu, the sequence is also contained within two other DNA clones that have characteristics strongly suggesting that they derive from other homoeotic genes.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
204,58 € per year
only 4,01 € per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Lewis, E. B. Nature 276, 565–570 (1978).
Kaufman, T. C., Lewis, R. & Wakimoto, B. Genetics 94, 115–133 (1980).
Lewis, R. A., Wakimoto, B. T., Denell, R. E. & Kaufman, T. C. Genetics 95, 383–397 (1980).
Wakimoto, B. T. & Kaufman, T. C. Devl Biol. 81, 51–64 (1981).
Hazelrigg, T. & Kaufman, T. C. Genetics 105, 581–600 (1983).
Le Calvez, J. Bull. biol. Fr. Belg. 82, 97–113 (1948).
Hannah, A. & Strömnaes, O. Drosoph. Inf. Serv. 29, 121–123 (1955).
Garcia-Bellido, A. Am. Zool. 17, 613–629 (1977).
Duncan, I. & Lewis, E. B. Developmental Order: Its Origin and Regulation, 533–554 (Alan R. Liss, New York, 1982).
Struhl, G. Proc. natn. Acad. Sci. U.S.A. 79, 7380–7384 (1982).
Struhl, G. J. Embryol. exp. Morph. 76, 297–331 (1983).
Hafen, E., Levine, M. & Gehring, W. J. Nature 307, 287–289 (1984).
Garber, R. L., Kuroiwa, A. & Gehring, W. J. EMBO J. 2, 2027–2036 (1983).
Nüsslein-Volhard, C., Wieschaus, E. & Jürgens, G. Verh. dt zool. Ges., 91–104 (1982).
Bender, W. et al. Science 221, 23–29 (1983).
Akam, M. EMBO J. 2, 2075–2084 (1983).
Scott, M. P. et al. Cell (in the press).
Hafen, E., Levine, M., Garber, R. L. & Gehring, W. J. EMBO J. 2, 617–623 (1983).
Levine, M., Hafen, E., Garber, R. L. & Gehring, W. J. EMBO J. 2, 2037–2046 (1983).
Maniatis, T. et al. Cell 15, 687–701 (1978).
Langer-Sofer, P. R., Levine, M. & Ward, D. C. Proc. natn. Acad. Sci. U.S.A. 79, 4381–4385 (1982).
Bender, W., Spierer, P. & Hogness, D. S. J. molec. Biol. 168, 17–33 (1983).
Kaufman, T. C. Genetics 90, 579–596 (1978).
Morata, G. & Garcia-Bellido, A. Wilhelm Roux's Arch. dev. Biol. 179, 125–143 (1976).
Sanchez-Herrero, E. & Morata, G. J. Embryol. exp. Morph. 76, 251–264 (1983).
Morata, G. & Kerridge, S. Nature 290, 778–781 (1981).
Poulson, D. F. Biology of Drosophila, 168–274 (ed. Demereo, M.) (Wiley, New York, 1950).
Chan, L. N. & Gehring, W. J. Proc. natn. Acad. Sci. U.S.A. 68, 2217–2221 (1971).
Wieschaus, E. & Gehring, W. J. Devl Biol. 50, 249–263 (1976).
Underwood, E. M., Turner, F. R. & Mahowald, A. P. Devl Biol. 74, 286–301 (1980).
Southern, E. J. molec. Biol. 98, 503–517 (1975).
Goldberg, D. A. Proc. natn. Acad. Sci. U.S.A. 77, 5794–5799 (1980).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
McGinnis, W., Levine, M., Hafen, E. et al. A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes. Nature 308, 428–433 (1984). https://doi.org/10.1038/308428a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/308428a0
