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Alteration of c-myc chromatin structure by avian leukosis virus integration

Abstract

The most common sites of integration of the leukosis virus (ALV) long terminal repeat (LTR) in bursal lymphomas and derivative cell lines correspond to a region encompassed by two major hypersensitive sites in the 5′ flanking region of the pre-integration, unrearranged c-myc gene. After integration of the ALV LTR, the major hypersensitive site within the avian c-myc oncogene region is within the proviral LTR, and the major hypersensitive sites normally found in uninfected cells 5′ to the first c-myc coding exon are no longer detectable.

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References

  1. Weintraub, H. & Groudine, M. Science 93, 848–853 (1976).

    Article  ADS  Google Scholar 

  2. Wu, C. Nature 284, 854–860 (1980).

    Article  ADS  Google Scholar 

  3. Kuo, T., Mandel, J. & Chambon, P. Nucleic. Acids Res. 7, 2105–2113 (1979).

    Article  CAS  Google Scholar 

  4. Stalder, J. et al. Cell 20, 451–460 (1980).

    Article  CAS  Google Scholar 

  5. Weintraub, H., Larsen, A. & Groudine, M. Cell 24, 333–344 (1981).

    Article  CAS  Google Scholar 

  6. Groudine, M. & Weintraub, H. Cell 24, 393–401 (1981).

    Article  CAS  Google Scholar 

  7. Burch, J. & Weintraub, H. Cell 33, 65–76 (1983).

    Article  CAS  Google Scholar 

  8. Weintraub, H., Beug, H., Groudine, M. & Graf, T. Cell 28, 931–940 (1982).

    Article  CAS  Google Scholar 

  9. Elgin, S. C. R. Cell 27, 413–415 (1981).

    Article  CAS  Google Scholar 

  10. Groudine, M., Eisenman, R. & Weintraub, H. Nature 292, 311–317 (1981).

    Article  ADS  CAS  Google Scholar 

  11. Conklin, K. F., Coffin, J. M., Robinson, H. L., Groudine, M. & Eisenman, R. Molec. cell. Biol 2, 638–652 (1982).

    Article  CAS  Google Scholar 

  12. Cremisi, C. Nucl. Acids Res. 9, 5949–5964 (1981).

    Article  CAS  Google Scholar 

  13. Cereghini, S. et al. Cold Spring Harb. Symp. quant. Biol. 47, 935–944 (1983).

    Article  Google Scholar 

  14. McGinnis, W., Shermoen, A. W., Heemskerk, J. & Beckendorf, S. K. Proc. natn. Acad. Sci. U.S.A. 80, 1063–1067 (1983).

    Article  ADS  CAS  Google Scholar 

  15. Shermoen, A. W. & Beckendorf, S. K. Cell 29, 601–607 (1982).

    Article  CAS  Google Scholar 

  16. Nasmyth, K. A. Cell 30, 567–578 (1982).

    Article  CAS  Google Scholar 

  17. Storb, U., Arp, B. & Wilson, R. Nature 294, 90–92 (1979).

    Article  ADS  Google Scholar 

  18. Roussel, M. et al. Nature 281, 452–455 (1979).

    Article  ADS  CAS  Google Scholar 

  19. Sheiness, D. et al. 33, 962–968 (1980).

  20. Sheiness, D. K., Hughes, S. H., Stubblefield, E. & Bishop, J. M. Virology 105, 415–424 (1980).

    Article  CAS  Google Scholar 

  21. Haywood, W. S., Neel, B. G. & Astrin, S. M. Nature 290, 475–480 (1981).

    Article  ADS  Google Scholar 

  22. Shen-Ong, G. L. C., Keath, E. J., Piccoli, S. P. & Cole, M. D. Cell 31, 443–452 (1982).

    Article  CAS  Google Scholar 

  23. Marcu, K. B. et al. Proc. natn. Acad. Sci. U.S.A. 80, 519–523 (1983).

    Article  ADS  CAS  Google Scholar 

  24. Della-Favera, R. et al.. Proc. natn. Acad. Sci. U.S.A. 79, 7824–7827 (1982).

    Article  ADS  Google Scholar 

  25. Taub, R. et al. Proc. natn. Acad. Sci. U.S.A. 79, 7837–7841 (1982).

    Article  ADS  CAS  Google Scholar 

  26. Della-Favera, R., Martinotti, S., Gallo, R. C., Erikson, J. & Croce, C. M. Science 219, 963–967 (1983).

    Article  ADS  Google Scholar 

  27. Erikson, J., Ar-Rushdi, A., Drwinga, H. L., Nowell, P. C. & Croce, C. M. Proc. natn. Acad. Sci. U.S.A. 80, 820–824 (1983).

    Article  ADS  CAS  Google Scholar 

  28. Watson, D. K., Reddy, E. P., Duesberg, P. H. & Papas, T. S. Proc. natn. Acad. Sci. U.S.A. 80, 2146–2150 (1983).

    Article  ADS  CAS  Google Scholar 

  29. Akiyama, Y. & Katos, S. Biken. J. 17, 105–116 (1974).

    CAS  PubMed  Google Scholar 

  30. Neel, B. G. et al. J. Virol. 44, 158–166 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  31. Ju, G. & Skalka, A. M. Cell 22, 379–386 (1980).

    Article  CAS  Google Scholar 

  32. Pachl, C., Schubach, W. H., Eisenman, R. & Linial, M. Cell 33, 335–344 (1983).

    Article  CAS  Google Scholar 

  33. Fung, T. Y-K., Crittenden, L. B. & Kung, H.-J. J. Virol. 44, 742–746 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  34. Cooper, G. M. & Neiman, P. E. Nature 292, 857–858 (1981).

    Article  ADS  CAS  Google Scholar 

  35. Rovigatti, V., Royler, C., Neel, B., Hayward, W. & Astrin, S. in Tumor Cell Heterogeneity, 319–330 (Academic, New York, 1982).

    Google Scholar 

  36. Payne, G. S., Bishop, J. M. & Varmus, H. E. Nature 295, 209–214 (1982).

    Article  ADS  CAS  Google Scholar 

  37. Rechavi, G., Givol, D. & Canaani, E. Nature 300, 607–611 (1982).

    Article  ADS  CAS  Google Scholar 

  38. Luciw, P. A., Bishop, J. M., Varmus, H. E. & Capecchi, M. R. Cell 33, 705–716 (1983).

    Article  CAS  Google Scholar 

  39. Jolly, D., Esty, A., Subramani, S., Freidmann, T. & Verma, I. Nucleic Acid Res. 11, 1855–1872 (1983).

    Article  CAS  Google Scholar 

  40. Schwartz, D. E., Tizard, R. & Gilbert, W. Cell 32, 853–869 (1983).

    Article  CAS  Google Scholar 

  41. Fromm, M. & Berg, P. J. molec. appl. Genet. 1, 457–481 (1982).

    CAS  Google Scholar 

  42. Wasylyk, B., Wasylyk, C., Augereau, P. & Chambon, P. Cell 32, 503–514 (1983).

    Article  CAS  Google Scholar 

  43. Mareau, P. et al. Nucleic Acids Res. 9, 6047–6068 (1981).

    Article  Google Scholar 

  44. Nordheim, A. & Rich, A. Nature 303, 674–679 (1983).

    Article  ADS  CAS  Google Scholar 

  45. Cantor, C. R. Cell 25, 293–295 (1981).

    Article  CAS  Google Scholar 

  46. Weintraub, H. Cell 32, 1191–1203 (1983).

    Article  CAS  Google Scholar 

  47. Dodgson, J. B., Strommer, J. & Engel, J. D. Cell 17, 879–888 (1979).

    Article  CAS  Google Scholar 

  48. Benton, W. D. & Davis, R. W. Science 196, 180–182 (1977).

    Article  ADS  CAS  Google Scholar 

  49. Robins, T., Bister, K., Garon, C., Papas, T. & Duesberg, P. J. Virol. 41, 635–642 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  50. Tabak, H. F. & Flavell, R. A. Nucleic Acids Res. 5, 2321–2332 (1978).

    Article  CAS  Google Scholar 

  51. Maniatis, T., Jeffrey, A. & Kleid, D. G. Proc. natn. Acad. Sci. U.S.A. 72, 1184–1188 (1975).

    Article  ADS  CAS  Google Scholar 

  52. Okazaki, W. et al. Avian Path. 98, 311–329 (1980).

    Article  Google Scholar 

  53. Hihara, H., Shimizu, T. & Yamamoto, H. Natn. Inst. Anim. Hlth Qt. 14, 163–173 (1974).

    CAS  Google Scholar 

Download references

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Schubach, W., Groudine, M. Alteration of c-myc chromatin structure by avian leukosis virus integration. Nature 307, 702–708 (1984). https://doi.org/10.1038/307702a0

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