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Myelin-associated glycoprotein in human retina

Abstract

The human retina is unmyelinated, but structural similarities have been noted between Müller cells, the main glial cell type of retina, and oligodendrocytes, the myelin-forming cells of the central nervous system1. We now show that antibodies against myelin-associated glycoprotein, a minor component of central and peripheral myelin so far found only in myelin and myelin-forming cells2–4, also stain Müller cells. Immunoblot analysis of retinal proteins indicates that the antigen detected is myelin associated glycoprotein. These results suggest a closer relationship between Müller cells and oligodendrocytes than previously suspected and raise questions about the functional role of myelin-associated glycoprotein.

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Stefansson, K., Molnar, M., Marton, L. et al. Myelin-associated glycoprotein in human retina. Nature 307, 548–550 (1984). https://doi.org/10.1038/307548a0

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