Abstract
Two B-cell-derived tumours, human Burkitt's lymphoma (BL) and murine plasmacytoma (MPC), are regularly associated with a distinctive form of chromosomal translocation (for reviews see refs 1, 2). In BL, the distal portion of chromosome 8 breaks off and is transposed, in most cases, to chromosome 14, known to carry the immunoglobulin heavy-chain locus3. In about 5% of the cases the same distal part of the chromosome 8 has moved to either chromosome 2 or 22, to the neighbourhood of the κ or the λ locus, respectively4,5. In MFC the distal region of chromosome 15 is transposed to the chromosome 12, known to carry the immunoglobulin heavy-chain locus6, or enters into reciprocal exchange with the κ locus-carrying chromosome 6 (ref. 7). Several laboratories have located c-myc, the cellular homologue of the MC29 retro viral oncogene v-myc, to human chromosome 8 (refs 8–10) and mouse chromosome 15 (refs 11–13). It has also been shown that the BL- and MFC-associated translocations remove the c-myc gene from its original site and transpose it into or close to one of the immunoglobulin gene clusters8,14–16. In view of the above findings we also looked for possible involvement of the c-myc gene in a B-cell-derived tumour of a third species, the rat. Rat immunocytomas of spontaneous origin carry a reciprocal translocation between chromosomes 6 and 7 (ref. 17). Here we have localized the c-myc locus to chromosome 7 of the rat. Moreover, we have found that the c-myc gene was rearranged in four of five immunocytomas carrying the characteristic chromosomal translocation.
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Sümegi, J., Spira, J., Bazin, H. et al. Rat c-myc oncogene is located on chromosome 7 and rearranges in immunocytomas with t(6:7) chromosomal translocation. Nature 306, 497–498 (1983). https://doi.org/10.1038/306497a0
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DOI: https://doi.org/10.1038/306497a0
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