Abstract
The predicted amino acid sequence of the simian sarcoma virus (SSV) transforming gene product, p28SIS, closely corresponds to that of human platelet-derived growth factor (PDGF). We demonstrate that p28SIS rapidly undergoes a series of discrete processing steps including dimer formation and proteolytic digestion to yield molecules structurally and immunologically resembling biologically active PDGF.
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Robbins, K., Antoniades, H., Devare, S. et al. Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor. Nature 305, 605–608 (1983). https://doi.org/10.1038/305605a0
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DOI: https://doi.org/10.1038/305605a0
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