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Functional identity between murine γ Interferon and macrophage activating factor


We have previously suggested that two lymphokine activities–macrophage activating factor (MAF) and γ interferon (IFN-γ)–are mediated by the same molecule1,2. Striking similarities were noted in their cellular biosynthesis, rate of inactivation with acid treatment and heating, and elution profiles on Sepha-cryl S-200. In addition, highly specific polyclonal antibodies to murine IFN-γ neutralized MAF and IFN-γ to a similar degree. However, definitive studies require a pure product and we now report that murine IFN-γ that had been cloned and expressed in a simian nonlymphoid cell line shows MAF activity. But it is not yet known whether IFN-γ is responsible for all the MAF activity in media conditioned by T cells as the possibility for MAF heterogeneity remains.

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Schultz, R., Kleinschmidt, W. Functional identity between murine γ Interferon and macrophage activating factor. Nature 305, 239–240 (1983).

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