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A cell-surface molecule involved in organ-specific homing of lymphocytes

Nature volume 304, pages 30–34 (1983)Cite this article

Abstract

Lymphocytes migrate from the bloodstream by recognizing and binding to specialized endothelial cells lining the high endothelial venules (HEV) in lymph nodes and Peyer's patches. We describe here a monoclonal antibody, MEL-14, specific for a lymphocyte surface molecule that appears to mediate recognition of lymph node HEV, and to be required for lymphocyte homing into lymph nodes in vivo.

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Authors and Affiliations

  1. Laboratory of Experimental Oncology, Department of Pathology, Stanford University School of Medicine, Stanford, California, 94305, USA

    W. Michael Gallatin, Irving L. Weissman & Eugene C. Butcher

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  1. W. Michael Gallatin
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  2. Irving L. Weissman
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  3. Eugene C. Butcher
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Gallatin, W., Weissman, I. & Butcher, E. A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature 304, 30–34 (1983). https://doi.org/10.1038/304030a0

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