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‘Hormonal’ risk factors, ‘breast tissue age’ and the age-incidence of breast cancer

Nature volume 303, pages 767–770 (1983)Cite this article

Abstract

For most cancer sites there is a linear log–log relationship between incidence and age. This relationship does not hold for breast cancer, and certain ‘key’ breast cancer risk factors suggest that breast tissue does not ‘age’ in step with calendar time. A quantitative description of ‘breast tissue age’ is suggested which brings the age–incidence curve of breast cancer into line with the common log–log cancers and explains quantitatively the known key risk factors. The model also explains the ‘anomalous’ finding that although early first birth is protective, late first birth carries a higher risk than nulliparity. US breast cancer rates are some four to six times the rates in Japan—the model suggests that the key risk factors, when considered jointly with weight, can explain about 85% of the difference.

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References

  1. MacMahon, B. et al. Bull. Wld Hlth Org. 43, 209–221 (1970).

    CAS  Google Scholar 

  2. Staszewski, J. J. natn. Cancer Inst. 47, 935–940 (1971).

    CAS  Google Scholar 

  3. Trichopoulos, D., MacMahon, B. & Cole, P. J. natn. Cancer Inst. 48, 605–613 (1972).

    CAS  Google Scholar 

  4. MacMahon, B., Cole, P. & Brown, J. J. natn. Cancer Inst. 50, 21–42 (1973).

    Article  CAS  Google Scholar 

  5. Pike, M. C. et al. Br. J. Cancer 43, 72–76 (1981).

    Article  CAS  Google Scholar 

  6. Miller, A. B. & Bulbrook, R. D. New Engl. J. Med. 303, 1246–1248 (1980).

    Article  CAS  Google Scholar 

  7. de Waard, F., Cornelis, J. P., Aoki, K. & Yoshida, M. Cancer 40, 1269–1275 (1977).

    Article  CAS  Google Scholar 

  8. Lew, E. A. & Garfinkel, L. J. chron. Dis. 32, 563–576 (1979).

    Article  CAS  Google Scholar 

  9. Cook, D. J., Doll, R. & Fellingham, S. A. Int. J. Cancer 4, 93–112 (1969).

    Article  CAS  Google Scholar 

  10. Peto, R. in Origins of Human Cancer (eds H. H. Hiatt, J. D. Watson & J. A. Winsten) (Cold Spring Harbor, New York, 1977).

    Google Scholar 

  11. Doll, R. & Peto, R. J. Epidem. comm. Hlth 32, 303–313 (1978).

    Article  CAS  Google Scholar 

  12. Pike, M. C., Henderson, B. E. & Casagrande, J. T. in Banbury Rep. 8, Hormones and Breast Cancer (eds M. C. Pike, P. K. Siiteri & C. W. Welsch) 3–18 (Cold Spring Harbor, New York, 1981).

    Google Scholar 

  13. Cutler, S. J. & Young, J. L. (eds) 3rd National Cancer Survey: Incidence Data (US Dpt of Health, Education and Welfare Publ. No. (NIH) 75-787, 1975).

  14. Brown, J. B. in Banbury Rep. 8, Hormones and Breast Cancer (eds M. C. Pike, P. K. Siiteri & C. W. Welsch) 33–54 (Cold Spring Harbor, New York, 1981).

    Google Scholar 

  15. Wallace, R. et al. Cancer Res. 38, 4021–4024 (1978).

    CAS  PubMed  Google Scholar 

  16. MacMahon, B. Age at Menarche (US Dpt of Health, Education and Welfare, Public Health Service Publ. No. 74-1615, Ser. 11, No. 133, 1973).

    Google Scholar 

  17. Department of Health, Education, and Welfare Fertility Tables for Birth Cohorts by Color: United States 1917–73. (US Dpt of Health, Education and Welfare Publ. No. (HRA) 76-1152, 1976).

  18. Department of Health, Education, and Welfare Infant, Fetal, and Maternal Mortality: United States—1963 (US Dpt of Health, Education and Welfare Public Health Service Publ. No. 1, Ser. 20, No. 3, 1966).

  19. MacMahon, B. & Worcester, J. Age at Menopause United States 1960–1962 (US Dpt of Health, Education and Welfare Public Health Service Publ. No. 1000, Ser. 11, No. 19, 1966).

    Google Scholar 

  20. Krailo, M. D. & Pike, M. C. Am. J. Epidem. 117, 356–361 (1983).

    Article  CAS  Google Scholar 

  21. Ross, R. K. et al. J. Am. med. Ass. 243, 1635–1639 (1980).

    Article  CAS  Google Scholar 

  22. Paganini-Hill, A. et al. Ann. intern. Med. 95, 28–31 (1981).

    Article  CAS  Google Scholar 

  23. Kwa, H. G. et al. Int. J. Cancer 28, 673–676 (1981).

    Article  CAS  Google Scholar 

  24. Pike, M. C. et al. J. natn. Cancer Inst. 53, 187–193 (1979).

    Google Scholar 

  25. Yu, M. C. et al. Br. J. Cancer 43, 826–831 (1981).

    Article  CAS  Google Scholar 

  26. Kwa, H. G. et al. Int. J. Cancer 28, 31–34 (1981).

    Article  CAS  Google Scholar 

  27. Cairns, J. Nature 255, 197–200 (1975).

    Article  ADS  CAS  Google Scholar 

  28. Haagensen, C. D. Diseases of the Breast (Saunders, Philadelphia, 1971).

    Google Scholar 

  29. Anderson, T. J., Ferguson, D. J. P. & Raab, G. M. Br. J. Cancer 46, 376–382 (1982).

    Article  CAS  Google Scholar 

  30. Ferguson, D. J. P. & Anderson, T. J. Br. J. Cancer 44, 177–181 (1981).

    Article  CAS  Google Scholar 

  31. Masters, J. R. W., Drife, J, O. & Scarisbrick, J. J. J. natn. Cancer Inst., 58, 1263–1265 (1977).

    Article  CAS  Google Scholar 

  32. Meyer, J. S. Hum. Path. 8, 67–81 (1977).

    Article  CAS  Google Scholar 

  33. Henderson, B. E., Pike, M. C. & Casagrande, J. T. Lancet i, 363 (1981).

    Article  Google Scholar 

  34. Office of Population Censuses and Surveys Decennial Supplement, Occupation and Mortality, 1970–72 (DS No. 1. HMSO, London, 1978).

  35. Janerich, D. T. Lancet i, 1240–1241 (1979).

    Article  Google Scholar 

  36. Siiteri, P. K., Hammond, G. L. & Nisker, J. A. in Banbury Rep. 8, Hormones and Breast Cancer (eds M. C. Pike, P. K. Siiteri & C. W. Welsch) 87–101 (Cold Spring Harbor, New York, 1981).

    Google Scholar 

  37. Kirschner, M. A., Ertel, N. & Schneider, G. Cancer Res. 41, 3711–3717 (1981).

    CAS  PubMed  Google Scholar 

  38. Waterhouse, J., Muir, C., Correa, P. & Powell, J. (eds) Cancer Incidence in Five Continents (IARC Scientific Publications No. 15, International Agency for Research on Cancer, Lyon, 1976).

  39. Fujimoto, I., Hanai, A. & Oshima, A. Natn. Cancer Inst. Monogr. 53, 5–15 (1979).

    Google Scholar 

  40. Buell, P. J. natn. Cancer Inst. 51, 1479–1483 (1973).

    Article  CAS  Google Scholar 

  41. Hoel, D. G., Wakabayashi, T. & Pike, M. C. Am. J. Epidem. (in the press).

  42. Moolgavkar, S. H., Stevens, R. G. & Lee, J. A. H. J. natn. Cancer Inst. 62, 493–501 (1979).

    Article  CAS  Google Scholar 

  43. Armstrong, B. & Doll, R. Int. J. Cancer 15, 617–631 (1975).

    Article  CAS  Google Scholar 

  44. Armitage, P. & Doll, R. Br. J. Cancer 8, 1–12 (1954).

    Article  CAS  Google Scholar 

  45. Moolgavkar, S. H. & Venzon, D. J. Math. Biosci. 47, 55–77 (1979).

    Article  Google Scholar 

  46. Moolgavkar, S. H., Day, N. E. & Stevens, R. G. J. natn. Cancer Inst. 65, 559–569 (1980).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Family and Preventive Medicine, University of Southern California Medical School, 2025 Zonal Avenue, Los Angeles, California, 90033, USA

    M. C. Pike, M. D. Krailo, B. E. Henderson & J. T. Casagrande

  2. National Institute for Environmental Health Sciences, Research Triangle Park, North Carolina, 27709, USA

    D. G. Hoel

Authors
  1. M. C. Pike
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  2. M. D. Krailo
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  3. B. E. Henderson
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  4. J. T. Casagrande
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  5. D. G. Hoel
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Pike, M., Krailo, M., Henderson, B. et al. ‘Hormonal’ risk factors, ‘breast tissue age’ and the age-incidence of breast cancer. Nature 303, 767–770 (1983). https://doi.org/10.1038/303767a0

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