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Growth of chromosome ends in multiplying trypanosomes

Nature volume 303, pages 592–597 (1983)Cite this article

Abstract

Some of the genes for the variant surface glycoproteins of trypanosomes are located close to a discontinuity in the DNA, presumably a chromosome end. We show here that DNA fragments containing these telomeres increase in length in multiplying trypanosomes at a rate of about 10 base pairs per division. We argue that chromosome growth may not be restricted to trypanosomes and could explain the heterogeneity of telomeric DNA fragments observed in some other organisms.

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Author notes

  1. André Bernards & Paul A. M. Michels

    Present address: The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands

Authors and Affiliations

  1. Section for Medical Enzytnology, Laboratory of Biochemistry, University of Amsterdam, Jan Swammerdam Institute, PO Box 60.000, 1005, GA, Amsterdam, The Netherlands

    André Bernards, Paul A. M. Michels, Carsten R. Lincke & Piet Borst

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  1. André Bernards
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  2. Paul A. M. Michels
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  3. Carsten R. Lincke
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  4. Piet Borst
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Bernards, A., Michels, P., Lincke, C. et al. Growth of chromosome ends in multiplying trypanosomes. Nature 303, 592–597 (1983). https://doi.org/10.1038/303592a0

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