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Strong homology in promoter and 3′-untranslated regions of chick and rat α-actin genes


We report here a comparison of the nucleotide sequences of the chick and rat skeletal muscle α-actin genes which reveals strongly conserved blocks of sequence in the putative transcriptional promoter and 3′-untranslated regions. This is the first instance of strong sequence conservation in untranslated gene regions between birds and mammals, other than the CAAT and ATA promoter homologies and the putative poly(A) addition signal, AATAAA1. The strong conservation of these sequences suggests that they may have a role in the tissue-specific expression of the skeletal muscle α-actin gene.

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  1. Breathnach, R. & Chambon, P. A. Rev. Biochem. 50, 349–383 (1981).

    Article  CAS  Google Scholar 

  2. Fornwald, J., Kuncio, G., Peng, I. & Ordahl, C. P. Nucleic Acids Res. 10, 3861–3876 (1982).

    Article  CAS  Google Scholar 

  3. Zakut, R. et al. Nature 298, 857–859 (1982).

    Article  ADS  CAS  Google Scholar 

  4. Hamada, H., Petrina, M. G. & Kakunaga, T. Proc. natn. Acad. Sci. U.S.A. 79, 5901–5905 (1982).

    Article  ADS  CAS  Google Scholar 

  5. Garfinkel, L. I., Perisamy, M. & Nadal-Ginard, B. J. biol. Chem. 257, 11078–11086 (1982).

    CAS  PubMed  Google Scholar 

  6. Cooper, A. D. & Crain, W. R. Nucleic Acids Res. 10, 4081–4092 (1982).

    Article  CAS  Google Scholar 

  7. Woo, S. L. C. et al. Biochemistry 20, 6437–6446 (1981).

    Article  CAS  Google Scholar 

  8. Perler, F. et al. Cell 20, 555–566 (1980).

    Article  CAS  Google Scholar 

  9. Jolly, D. J. et al. Proc. natn. Acad. Sci. U.S.A. 80, 477–481 (1983).

    Article  ADS  CAS  Google Scholar 

  10. Konecki, D. S., Brennard, J., Fuscoe, J. C., Caskey, C. T. & Chinault, A. C. Nucleic Acids Res. 10, 6763–6775 (1982).

    Article  CAS  Google Scholar 

  11. Cochet, M. et al. Nature 282, 567–574 (1979).

    Article  ADS  CAS  Google Scholar 

  12. Grez, M. et al. Cell 25, 743–752 (1981).

    Article  CAS  Google Scholar 

  13. Mahdavi, V., Periasamy, M. & Nadal-Ginard, B. Nature 297, 659–664 (1982).

    Article  ADS  CAS  Google Scholar 

  14. Lawn, R. M., Efstratiadis, A., O'Connell, C. & Maniatis, T. Cell 21, 647–651 (1980).

    Article  CAS  Google Scholar 

  15. Schon, E. A., Cleary, M. L., Haynes, J. R. & Lingrel, J. B. Cell 27, 359–369 (1981).

    Article  CAS  Google Scholar 

  16. Jeltsch, J. M. & Chambon, P. Eur. J. Biochem. 122, 291–295 (1982).

    Article  CAS  Google Scholar 

  17. Degrave, W., Derynck, R., Tavernier, J., Haegeman, G. & Fiers, W. Gene 14, 137–143 (1981).

    Article  CAS  Google Scholar 

  18. Efstratiadis, A. et al. Cell 21, 653–668 (1980).

    Article  CAS  Google Scholar 

  19. Davidson, E. H., Jacobs, H. T. & Britten, R. J. Nature 301, 468–470 (1983).

    Article  ADS  CAS  Google Scholar 

  20. Devlin, R. B. & Emerson, C. P. Cell 13, 599–611 (1978).

    Article  CAS  Google Scholar 

  21. Ordahl, C. P. et al. in Muscle Development: Molecular and Cellular Control (eds Pearson, M. L. & Epstein, H. F.) (Cold Spring Harbor Laboratory, New York, 1982).

    Google Scholar 

  22. Nudel, U. et al. Nucleic Acids Res. 11, 1759–1771 (1983).

    Article  CAS  Google Scholar 

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Ordahl, C., Cooper, T. Strong homology in promoter and 3′-untranslated regions of chick and rat α-actin genes. Nature 303, 348–349 (1983).

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