Different classes of intermediate filaments are restricted to particular cell types1. For example, neurofilaments are found only in neurones2–6, whereas filaments that contain the protein vimentin, which were found in some cells of mesenchymal origin and some forms of glia4,5,7,8, are thought to be absent from mature neurones, and present only transiently in early embryonic neurones6,9. However, evidence is presented here of an exception to that rule in the outer plexif orm layer of the mouse retina. Double-labelling with antibodies to neurofilaments and vimentin showed that both types of intermediate filaments coexisted in the axonless horizontal cell of that retinal layer, recalling the previous notion that these cells are glial or intermediate between neuronal and glial (reviewed in ref. 10).
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Lazarides, E. Nature 283, 249–256 (1980).
Liem, R. K. H., Yen, S-H., Salomon, G. D. & Shelanski, M. L. J. Cell Biol. 79, 637–645 (1978).
Schachner, M., Smith, C. & Schoonmaker, G. Devl Neurosci. 1, 1–14 (1978).
Yen, S-H. & Fields, K. L. J. Cell Biol. 88, 115–126 (1981).
Shaw, G., Osborn, M. & Weber, K. Eur. J. Cell Biol. 26, 68–82 (1981).
Jacobs, M., Choo, Q. L. & Thomas, C. J. Neurochem. 38, 969–977 (1982).
Franke, W. W., Schmid, E., Osborn, M. & Weber, K. Proc. natn. Acad. Sci. U.S.A. 75, 5034–5038 (1978).
Schnitzer, J., Franke, W. W. & Schachner, M. J. Cell Biol. 90, 435–447 (1981).
Bignami, A., Raju, T. & Dahl, D. Devl Biol. 91, 286–295 (1982).
Wässle, H., Peichl, L. & Boycott, B. B. Proc. R. Soc. B203, 269–292 (1978).
Gray, E. G. & Guillery, R. W. J. Physiol., Lond. 157, 581–588 (1961).
Potter, H. D. J. comp. Neurol. 143, 385–410 (1971).
Gambetti, P., Autilio-Gambetti, L. & Papasozomenos, S. C. Science 213, 1521–1522 (1981).
Fisher, S. K. & Boycott, B. B. Proc. R. Soc. B186, 317–331 (1974).
Kolb, H. J. Neurocytol. 6, 131–153 (1977).
Bignami, A. & Dahl, D. Expl Eye Res. 28, 63–69 (1979).
Dahl, D., Bignami, A., Weber, K. & Osborn, M. Expl Neurol. 73, 496–506 (1981).
Dixon, A. S. & Eng, L. F. J. comp. Neurol. 195, 305–321 (1981).
Vrabrec, F. J. Neuropath. exp. Neurol. 29, 217–224 (1970).
Boycott, B. B. & Hopkins, J. M. Neuroscience 6, 679–688 (1981).
Anderton, B. H. et al. Nature 298, 84–86 (1982).
Hynes, R. O. & Destree, A. T. Cell 13, 151–163 (1978).
Springer, T., Galfre, G., Secher, D. S. & Milstein, C. Eur. J. Immun. 9, 301–306 (1979).
Ho, M.-K. & Springer, T. A. J. Immun. 128, 1221–1228 (1982).
Ho, M.-K. & Springer, T. A. J. biol Chem. 258, 636–642 (1983).
Raff, M. C. et al. Brain Res. 174, 283–308 (1979).
Peters, A., Palay, S. & Webster, H. de F. The Fine Structure of the Nervous System (Saunders, Philadelphia, 1976).
Gallego, A. in The Structure of the Eye (ed. Hollyfield, J. G.)151–164 (Elsevier, Amsterdam, 1982).
Boycott, B. B., Peichl, L. & Wässle, H. Proc. R. Soc. B203, 229–245 (1978).
Bloomfield, S. A. & Miller, R. F. J. comp. Neurol. 208, 288–303 (1982).
Dacheux, R. F. & Raviola, E. J. Neurosci. 2, 1486–1493 (1982).
Boycott, B. B. & Kolb, H. J. comp. Neurol. 148, 115–140 (1973).
Kolb, H., Mariani, A. & Gallego, A. J. comp. Neurol. 189, 31–44 (1980).
Kolb, H. J. comp. Neurol. 155, 1–14 (1974).
Baylor, D. A., Fuortes, M. G. F. & O'Bryan, P. M. J. Physiol., Lond. 214, 265–294 (1971).
Werblin, F. S. & Dowling, J. E. J. Neurophysiol. 32, 339–355 (1969).
Kaneko, A. J. Physiol., Lond. 207, 623–633 (1970).
Svaetichin, G., Negishi, K., Fatehchand, R., Drujan, B. D. & Selvin de Testa, A. Prog. Brain Res. 15, 243–266 (1965).
Raviola, E. & Gilula, N. B. J. Cell Biol. 65, 192–222 (1975).
Rights and permissions
About this article
Cite this article
Dräger, U. Coexistence of neurofilaments and vimentin in a neurone of adult mouse retina. Nature 303, 169–172 (1983). https://doi.org/10.1038/303169a0
This article is cited by
Characterization of dsRed2-positive cells in the doublecortin-dsRed2 transgenic adult rat retina
Histochemistry and Cell Biology (2014)
Diurnal rodents as animal models of human central vision: characterisation of the retina of the sand rat Psammomys obsesus
Graefe's Archive for Clinical and Experimental Ophthalmology (2011)
Lamina formation in the Mongolian gerbil retina (Meriones unguiculatus)
Anatomy and Embryology (2005)
Intermediate filaments in the nervous system: implications in cancer
Cancer and Metastasis Review (1996)
Expression of neurofilament proteins by horizontal cells in the rabbit retina varies with retinal location
Journal of Neurocytology (1995)
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.