Abstract
Recently, some of us reported1 the detection and molecular cloning of a rearranged cellular oncogene, designated rc-mos, from a non-virally-induced mouse myeloma, XRPC24. Recombinant λ phage DNA containing the rc-mos gene was active in transforming NIH 3T3 cells in a transfection assay, whereas recombinant DNA containing the unrearranged c-mos gene was not. In rc-mos, coding sequences from the 5′ end of c-mos were found to have been displaced by a novel cellular element whose nucleotide sequence was reported. We now document the fact that a 349-base pair (bp) segment of the novel DNA immediately adjacent to the retained c-mos sequences in rc-mos has close homology with the long terminal repeat (LTR) of a known intracisternal A-particle gene. This homology was mentioned in Nature recently2 after it had been brought to the attention of the editors (N. Hozumi and R. Hawley, personal communication).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Rechavi, G., Givol, D. & Canaani, E. Nature 300, 607–611 (1982).
Newmark, P. Nature 301, 196 (1983).
Dalton, A., Potter, M. & Merwin, R. M. J. natn. Cancer Inst. 26, 1221 (1961).
Lueders, K. K. & Kuff, E. L. Cell 12, 963 (1977).
Lueders, K. K. & Kuff, E. L. Proc. natn. Acad. Sci. U.S.A. 77, 3571 (1980).
Ono, M., Cole, M. D., White, A. T. & Huang, R. C. Cell 21, 465 (1980).
Kuff, E. L., Smith, L. A. & Lueders, K. K. Molec. cell. Biol. 1, 216 (1981).
Cole, M. D., Ono, M. & Huang, K. C. J. Virol. 38, 680 (1981).
Sheng-Ong, G. L. C. & Cole, M. D. J. Virol. 42, 411 (1982).
Hawley, R. G., Shulman, M. J., Murialdo, H., Gibson, D. M. & Hozumi, N. Proc. natn. Acad. Sci. U.S.A. 79, 7425 (1982).
Kuff, E. L. et al. Proc. natn. Acad. Sci. U.S.A. (in the press).
Varmus, H. E. Science 216, 812 (1982).
Wilber, W. G. & Lipman, D. J. Proc. natn. Acad. Sci. U.S.A. 80, 726 (1983).
Hayward, W. S., Neel, B. G. & Astrin, S. M. Nature 290, 475–480 (1981).
Payne, G. S., Bishop, J. M. & Varmus, H. E. Nature 295, 209–214 (1982).
Jenkins, N. A., Copeland, N. G., Taylor, B. A. & Lee, B. K. Nature 293, 370–374 (1981).
Jaenish, R. et al. Cell 32, 209 (1982).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kuff, E., Feenstra, A., Lueders, K. et al. Homology between an endogenous viral LTR and sequences inserted in an activated cellular oncogene. Nature 302, 547–548 (1983). https://doi.org/10.1038/302547a0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/302547a0
This article is cited by
-
The intracisternal A particle derived solo LTR promoter of the rat oncomodulin gene is not present in the mouse gene
Genetica (1992)
-
Localization of human c-mos to chromosome band 8q11 in leukemic cells with the t(8;21) (q22;q22)
Human Genetics (1989)
-
Isolation and characterization of a family of rat endogenous retroviral sequences
Virus Genes (1989)
-
Homology between IgE-binding factor and retrovirus genes
Nature (1986)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.