Letter | Published:

Homology between an endogenous viral LTR and sequences inserted in an activated cellular oncogene

Naturevolume 302pages547548 (1983) | Download Citation

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Abstract

Recently, some of us reported1 the detection and molecular cloning of a rearranged cellular oncogene, designated rc-mos, from a non-virally-induced mouse myeloma, XRPC24. Recombinant λ phage DNA containing the rc-mos gene was active in transforming NIH 3T3 cells in a transfection assay, whereas recombinant DNA containing the unrearranged c-mos gene was not. In rc-mos, coding sequences from the 5′ end of c-mos were found to have been displaced by a novel cellular element whose nucleotide sequence was reported. We now document the fact that a 349-base pair (bp) segment of the novel DNA immediately adjacent to the retained c-mos sequences in rc-mos has close homology with the long terminal repeat (LTR) of a known intracisternal A-particle gene. This homology was mentioned in Nature recently2 after it had been brought to the attention of the editors (N. Hozumi and R. Hawley, personal communication).

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Author information

Affiliations

  1. Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205, USA

    • Edward L. Kuff
    • , Anita Feenstra
    •  & Kira Lueders
  2. Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, 76100, Israel

    • Gideon Rechavi
    • , David Givol
    •  & Eli Canaani

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https://doi.org/10.1038/302547a0

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