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Infectious vaccinia virus recombinants that express hepatitis B virus surface antigen

Naturevolume 302pages490495 (1983) | Download Citation

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Abstract

Potential live vaccines against hepatitis B virus have been produced. The coding sequence for hepatitis B virus surface antigen (HBsAg) has been inserted into the vaccinia virus genome under control of vaccinia virus early promoters. Cells infected with these vaccinia virus recombinants synthesize and excrete HBsAg and vaccinated rabbits rapidly produce antibodies to HBsAg.

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References

  1. 1

    Jenner, E., Inquiry into the Causes and Effects of the Variolae Vaccinae, a Disease Discovered in some Western Counties of England, particularly Gloucestershire, and known by the Name of Cow Pox. 1798. (Reprint: Cassell, London, 1896).

  2. 2

    Weir, J. P., Bajszar, G. & Moss, B. Proc. natn. Acad. Sci. U.S.A. 79, 1210–1214 (1982).

  3. 3

    Panicalli, D. & Paoletti, E. Proc. natn. Acad. Sci. U.S.A. 79, 4927–4931 (1982).

  4. 4

    Mackett, M., Smith, G. L. & Moss, B. Proc. natn. Acad. Sci. U.S.A. 79, 7415–7419 (1982).

  5. 5

    Venkatesan, S., Baroudy, B. M. & Moss, B. Cell 125, 805–813 (1981).

  6. 6

    Venkatesan, S., Gershowitz, A. & Moss, B. J. Virol. 44, 637–646 (1982).

  7. 7

    Sam, C. K. & Dumbell, K. R. Ann. Virol. Inst. Pasteur, Paris 132 E, 135–150 (1981).

  8. 8

    Nakano, E., Panicalli, D. & Paoletti, E. Proc. natn. Acad. Sci. U.S.A. 79, 1593–1596 (1982).

  9. 9

    Hruby, E. D. & Ball, L. A. J. Virol. 43, 403–409 (1982).

  10. 10

    Bajszar, G., Wittek, R., Weir, J. P. & Moss, B. J. Virol. 45, 62–72 (1983).

  11. 11

    Charnay, P., Pourcel, C., Louise, A., Fritsch, A. & Tiollas, P. Proc. natn. Acad. Sci. U.S.A. 76, 2222–2226 (1979).

  12. 12

    Burrell, C. J., Mackay, P., Greenway, P. J., Hofschneider, P. H. & Murray, K. Nature 279, 43–47 (1979).

  13. 13

    Sninsky, J. J., Siddiqui, A., Robinson, W. S. & Cohen, S. N. Nature 279, 346–348 (1979).

  14. 14

    Valenzuela, P. et al. Nature 280, 815–819 (1979).

  15. 15

    Galibert, F., Mandart, E., Fitoussi, F., Tiollas, P. & Charnay, P. Nature 281, 646–650 (1979).

  16. 16

    Pasek, M. et al. Nature 282, 575–579 (1979).

  17. 17

    MacKay, P. et al. Proc. natn. Acad. Sci. U.S.A. 78, 4510–4514 (1981).

  18. 18

    Valenzuela, P., Medina, A., Rutter, W. J., Ammerer, G. & Hall, B. D. Nature 298, 347–350 (1982).

  19. 19

    Moriarity, A. M., Hoyer, B. H., Shih, J. W.-k, Gerin, J. L. & Hamer, D. H. Proc. natn. Acad. Sci. U.S.A. 78, 2606–2610 (1981).

  20. 20

    Liu, C.-C., Yansura, D. & Levinson, A.D. DNA 1, 213–221 (1982).

  21. 21

    Villarreal, L. P. & Berg, P. Science 196, 183–185 (1977).

  22. 22

    Gerin, J. L., Holland, P. V. & Purcell, R. H. J. Virol. 7, 569–576 (1977).

  23. 23

    Macnab, G. M., Alexander, J. J., Letcasas, G., Bey, E. M. & Urbanowicz, J. M. Br. J. Cancer 34, 509–515 (1976).

  24. 24

    Marion, P. L., Salazar, F. H., Alexander, J. J. & Robinson, W. J. Virol. 32, 796–802 (1979).

  25. 25

    Peterson, D. L. J. biol. Chem. 256, 6975–6983 (1981).

  26. 26

    Courouce-Pauty, A. M., Naret, C., Ciancionni, C., Adhemar, J. P. & Soulier, J. P. Transplant. clin. Immun. 10, 77–85 (1978).

  27. 27

    Purcell, R. H. & Gerin, J. L. Rev. infect. Dis. 2, 470–492 (1980).

  28. 28

    Denhardt, D. T. Biochem. biophys. Res. Commun. 23, 641–646 (1966).

  29. 29

    Gerety, R. J., Smallwood, L. A. & Tabor, E. New Engl. J. Med. 303, 529 (1980).

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  1. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20205, USA

    • Geoffrey L. Smith
    • , Michael Mackett
    •  & Bernard Moss

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https://doi.org/10.1038/302490a0

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