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Rearranged mitochondrial genes in the yeast nuclear genome

Abstract

We have found a contiguous DNA sequence in the yeast nuclear genome with extensive homology to non-contiguous yeast mitochondrial DNA sequences. Closely linked to this nuclear sequence in some, but not all, yeast strains is a tandem pair of transposable (Ty) elements. Certain features of the content and organization of this nuclear DNA sequence suggest that it may have originated from petite mitochondrial DNA which integrated into the nuclear genome.

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References

  1. Borst, P. & Grivell, L. A. Cell 15, 705–723 (1978).

    Article  CAS  PubMed  Google Scholar 

  2. Butow, R. A. & Strausberg, R. L. Trends biochem. Sci. 4, 110–113 (1979).

    Article  CAS  Google Scholar 

  3. Tzagoloff, A., Macino, G. & Sebald, W. A. Rev. Biochem. 48, 419–441 (1979).

    Article  CAS  Google Scholar 

  4. Terpstra, P., Zanders, E. & Butow, R. A. J. biol. Chem. 254, 12653–12661 (1979).

    CAS  PubMed  Google Scholar 

  5. Terpstra, P. & Butow, R. A. J. biol. Chem. 254, 12662–12669 (1979).

    CAS  PubMed  Google Scholar 

  6. Groot, G. S. P., Mason, T. L. & Van Harten–Loosbroek, N. Molec. gen. Genet. 174, 339–342 (1979).

    Article  CAS  PubMed  Google Scholar 

  7. Lambowitz, A. M., Chua, N.-H. & Luck, D. J. L. J. molec. Biol. 107, 223–253 (1876).

    Article  Google Scholar 

  8. LaPolla, R. J. & Lambowitz, A. M. J. biol. Chem. 356, 7064–7067 (1981).

    Google Scholar 

  9. Tait, A., Knowles, J. K. C., Hardy, J. C. & Lipps, H. in Genetics and Biogenesis of Chloroplasts and Mitochondria (eds Bucher, T., Neupert, W., Sebald, W. & Werner, S.) 569–572 (North-Holland, Amsterdam, 1976).

    Google Scholar 

  10. Perasso, R., Curgy, J.-J., Iftode, F. & Andre, J. in The Organization and Expression of the Mitochondrial Genome (eds Kroon, A. M. & Saccone, I. C.) 675–694 (Elsevier, Amsterdam, 1980).

    Google Scholar 

  11. Leaver, C. J., Forde, B. G., Dixon, L. K. & Fox, T. D. in Mitochondrial Genes (eds Slonimski, P. P., Borst, P. & Attardi, G.) 457–470 (Cold Spring Harbor Laboratory, New York, 1982).

    Google Scholar 

  12. Hudspeth, M. E. S., Ainley, W. M., Shumard, D. S., Butow, R. A. & Grossman, L. I. Cell 30, 617–626 (1982).

    Article  CAS  PubMed  Google Scholar 

  13. Anderson, S. et al. Nature 290, 457–465 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  14. Anderson, S. et al. J. molec. Biol. 156, 683–717 (1982).

    Article  CAS  PubMed  Google Scholar 

  15. Bibb, M. J., Van Etten, R. A., Wright, C. T., Walberg, M. W. & Clayton, D. A. Cell 26, 167–180 (1981).

    Article  CAS  PubMed  Google Scholar 

  16. Ching, E. & Attardi, G. Biochemistry 21, 3188–3195 (1982).

    Article  CAS  PubMed  Google Scholar 

  17. Lazowska, J., Jacq, C. & Slonimski, P. P. Cell 22, 333–348 (1980).

    Article  CAS  PubMed  Google Scholar 

  18. Mahler, H. R. et al. in Mitochondrial Genes (eds Slonimski, P. P., Borst, P. & Attardi, G.) 185–199 (Cold Spring Harbor Laboratory, New York, 1982).

    Google Scholar 

  19. Weiss-Brummer, B., Rodel, G., Schweyen, R. & Kaudewitz, F. Cell 29, 527–536 (1982).

    Article  CAS  PubMed  Google Scholar 

  20. Barrell, B. G., Bankier, A. T. & Drouin, J. Nature 282, 189–194 (1979).

    Article  ADS  CAS  PubMed  Google Scholar 

  21. Bonitz, S. G. et al. Proc. natn. Acad. Sci. U.S.A. 77, 3167–3170 (1980).

    Article  ADS  CAS  Google Scholar 

  22. Young, I. G. & Anderson, S. Gene 12, 257–265 (1980).

    Article  CAS  PubMed  Google Scholar 

  23. Heckman, J. E., Sarnoff, J., Alzner-DeWeerd, B., Yin, S. & RajBhandary, U. L. Proc. natn. Acad. Sci. U.S.A. 77, 3159–3163 (1980).

    Article  ADS  CAS  Google Scholar 

  24. Orian, J. M., Murphy, M. & Marzuki, S. Biochim. biophys. Acta 652, 234–239 (1981).

    Article  CAS  PubMed  Google Scholar 

  25. Jackl, G. & Sebald, W. Eur. J. Biochem. 54, 97–106 (1975).

    Article  CAS  PubMed  Google Scholar 

  26. van den Boogaart, P., Samallo, J. & Agsteribbe, E. Nature 298, 187–189 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  27. Blanc, H. & Dujon, B. Proc. natn. Acad. Sci. U.S.A. 77, 3942–3946 (1980).

    Article  ADS  CAS  Google Scholar 

  28. deZamaroczy, M. et al. Nature 292, 75–78 (1981).

    Article  ADS  CAS  Google Scholar 

  29. Cameron, J. R., Loh, E. Y. & Davis, R. W. Cell 16, 739–751 (1979).

    Article  CAS  PubMed  Google Scholar 

  30. Roeder, G. S., Farabaugh, P. J., Chaliff, D. T. & Fink, G. R. Science 209, 1375–1379 (1980).

    Article  ADS  CAS  PubMed  Google Scholar 

  31. Tschumper, G. & Carbon, J. J. molec. Biol. 156, 293–307 (1982).

    Article  CAS  PubMed  Google Scholar 

  32. Perlman, P. S., Douglas, M. G., Strausberg, R. L. & Butow, R. A. J. molec. Biol. 115, 675–694 (1977).

    Article  CAS  PubMed  Google Scholar 

  33. Vincent, R. D., Perlman, P. S., Strausberg, R. L. & Butow, R. A. Curr. Genet. 2, 27–38 (1980).

    Article  CAS  PubMed  Google Scholar 

  34. Lopez, I. C., Farrelly, F. & Butow, R. A. J. biol. Chem. 256, 6496–6501 (1981).

    CAS  PubMed  Google Scholar 

  35. Bernardi, G. J. molec. Evol. 9, 25–35 (1976).

    Article  ADS  CAS  PubMed  Google Scholar 

  36. Nobrega, F. G. & Tzagoloff, A. J. biol. Chem. 255, 9828–9837 (1980).

    CAS  PubMed  Google Scholar 

  37. Barnardi, G. et al. in The Organization and Expression of the Mitochondrial Genome (eds Kroon, A. M. & Saccone, I. C.) 21–31 (Elsevier, Amsterdam, 1980).

    Google Scholar 

  38. Locker, J. M. & Rabinowitz, M. Plasmid 2, 155–181 (1979).

    Article  CAS  PubMed  Google Scholar 

  39. Gaillard, C. G., Stauss, F. & Bernardi, G. Nature 283, 218–220 (1980).

    Article  ADS  CAS  PubMed  Google Scholar 

  40. Blanc, H. & Dujon, B. in Mitochondrial Genes (eds Slominski, P. P., Borst, P., & Attardi, G.) 279–284 (Cold Spring Harbor Laboratory, New York, 1982).

    Google Scholar 

  41. Vanin, E. F., Goldberg, G. I., Tucker, P. W. & Smithies, O. Nature 286, 222–226 (1980).

    Article  ADS  CAS  PubMed  Google Scholar 

  42. Nishioka, Y., Leder, A. & Leder, P. Proc. natn. Acad. Sci. U.S.A. 77, 2806–2809 (1980).

    Article  ADS  CAS  Google Scholar 

  43. Hollis, G. F., Hieter, P. A., McBride, O. W., Swan, D. & Leder, P. Nature 296, 321–325 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  44. Wilde, C. D., Crowther, C. E. & Cowan, N. J. Science 217, 549–552 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  45. Jagadeeswaran, P., Forget, B. G. & Weissman, S. M. Cell 26, 141–142 (1981).

    Article  CAS  PubMed  Google Scholar 

  46. Goff, S. P., Gilboa, E., Witte, O. & Baltimore, D. Cell 22, 777–785 (1980).

    Article  CAS  PubMed  Google Scholar 

  47. Van Arsdell, S. W. et al. Cell 26, 11–18 (1981).

    Article  CAS  PubMed  Google Scholar 

  48. Frederick, J.F. (ed.) Origins and Evolution of Eukaryotic Intracellular Organelles (Annals of the New York Academy of Sciences, 1981).

  49. Perler, F. et al. Cell 20, 555–566 (1980).

    Article  CAS  PubMed  Google Scholar 

  50. Jacobs, H. T., Posakony, J. W., Grula, J. T., Davidson, E. H. & Britten, R. J. J. cell. Biochem. Suppl. 6, 817 (1982).

    Google Scholar 

  51. Hudspeth, M. E. S., Shumard, D. S., Tatti, K. M. & Grossman, L. I. Biochim. biophys. Acta 610, 221–228 (1980).

    Article  CAS  PubMed  Google Scholar 

  52. Kramer, R. A. & Anderson, N. Proc. natn. Acad. Sci. U.S.A. 77, 6541–6545 (1980).

    Article  ADS  CAS  Google Scholar 

  53. Maxam, A. & Gilbert, W. Meth. Enzym. 65, 499–560 (1980).

    Article  CAS  PubMed  Google Scholar 

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Farrelly, F., Butow, R. Rearranged mitochondrial genes in the yeast nuclear genome. Nature 301, 296–301 (1983). https://doi.org/10.1038/301296a0

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