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Targeted integration of baboon endogenous virus in the BEVI locus on human chromosome 6

Nature volume 301, pages 129132 (13 January 1983) | Download Citation

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Abstract

The infection of cultured human cells with baboon endogenous virus (BEV) frequently leads to an association of viral DNA with a specific genetic locus (termed BEVI, for baboon endogenous virus infection) on chromosome 6. Restriction endonuclease digestion of DNA from BEV-infected human cells and their derived somatic cell clones frequently revealed a common cellular DNA sequence in the proximity of one of the junctions between cellular DNA and the integrated virus. We propose that a short cellular DNA sequence, repeated on chromosome 6 and separated by unique DNA sequences, presents a high-affinity target for the integration of BEV in human cells.

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Affiliations

  1. Department of Medicine and Biochemistry, Louisiana State University, School of Medicine, New Orleans, Louisiana 70112, USA

    • J. Craig Cohen
  2. Department of Pediatrics, Tulane University, School of Medicine, New Orleans, Louisiana 70112, USA

    • Michael Murphey-Corb

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https://doi.org/10.1038/301129a0

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