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Distinct organizations and patterns of expression of early and late histone gene sets in the sea urchin

Nature volume 301, pages 120125 (13 January 1983) | Download Citation

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Abstract

The set of histone genes that are active late in embryogenesis of the sea urchin (Strongylocentrotus purpuratus) are present in 5–12 copies per genome and, unlike the clustered, tandemly arrayed early histone genes, are dispersed and irregularly arranged. Late H2B gene expression is activated by events accompanying fertilization and its mRNAs are first detectable by as early as 6 h of development (16 cells) and increase only slightly in amount during the period of rapid cleavage between 6 and 14 h. However, during the short interval between 14 and 16 h, while the amount of early histone mRNA is declining, there is a >15-fold burst in the rate of late H2B mRNA accumulation.

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Author notes

    • Timothy Mohun
    •  & Geoffrey Childs

    Present addresses: Medical Research Council, Laboratory of Molecular Biology, The Medical School, Hills Road, Cambridge CB2 2QH, UK (T.M.); Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA (G.C.).

Affiliations

  1. Department of Medicine, Stanford University School of Medicine and Veterans Administration Medical Center, Palo Alto, California 94305, USA

    • Robert Maxson
    • , Timothy Mohun
    • , Glen Gormezano
    • , Geoffrey Childs
    •  & Larry Kedes

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https://doi.org/10.1038/301120a0

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