Letter | Published:

β-Endorphin regulates lordosis in female rats by modulating LH-RH release

Nature volume 301, pages 6264 (06 January 1983) | Download Citation

Subjects

Abstract

Several lines of evidence have implicated the endogenous opioid peptides in the regulation of masculine sexual behaviour1–10. However, although the opioid related peptides α-melanocyte stimulating hormone (α-MSH)11,12 and adrenocorticotropin ( ACTH)13 have been shown to affect lordosis behaviour in the female rat, there is as yet no evidence for a role of the endogenous opiates in the regulation of female sexual behaviour. We present here evidence that the endogenous opiates in the mesencephalic central grey (MCG) are involved in the control of lordosis behaviour in the female rat.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    & Eur. J. Pharmac. 42, 191–192 (1977).

  2. 2.

    & Archs gen. Psychiat. 34, 1179–1180 (1977).

  3. 3.

    , , , & Life Sci. 23, 673–678 (1978).

  4. 4.

    , & Soc. Neurosci. Abstr. 5, 470 (1979).

  5. 5.

    & Pharmac. Biochem. Behav. 10, 615–618 (1979).

  6. 6.

    et al. Experientia 35, 524–525 (1979).

  7. 7.

    , & Pharmac. Biochem. Behav. 13, 435–442 (1980).

  8. 8.

    & Pharmac. Biochem. Behav. 12, 365–370 (1980).

  9. 9.

    , & Pharmac. Biochem. Behav. 13, 663–672 (1980).

  10. 10.

    , & Eur. J. Pharmac. 70, 279–285 (1981).

  11. 11.

    , & Physiol. Behav. 22, 447–450 (1979a).

  12. 12.

    , & Psychopharmacology 74, 153–156 (1981).

  13. 13.

    , & Horm. Behav. 13, 293–300 (1979).

  14. 14.

    , , & Nature 275, 226–228 (1978).

  15. 15.

    , , , & Proc. natn. Acad. Sci. U.S.A. 75, 1591–1595 (1978).

  16. 16.

    , , , & Neurosci. Lett. 5, 25–31 (1977).

  17. 17.

    et al. Proc. natn. Acad. Sci. U.S.A. 74, 3081–3085 (1977).

  18. 18.

    , , , & J. comp. Neurol. 182, 17–37 (1977).

  19. 19.

    & Brain Res. 129, 1–12 (1977).

  20. 20.

    , & J. comp. Neurol. 83, 785–816 (1979).

  21. 21.

    & Brain Res. 157, 233–246 (1978).

  22. 22.

    & Neurosci. Lett. 20, 1–4 (1980).

  23. 23.

    & Am. J. Physiol. 237, R278–R284 (1979).

  24. 24.

    & Brain Res. Bull. 4, 203–205 (1979).

  25. 25.

    & Nature 283, 566–567 (1980).

  26. 26.

    , , , & Neuroendocrinology 31, 66–72 (1980).

  27. 27.

    , , , & Neuroendocrinology 32, 163–167 (1981).

  28. 28.

    Endocrinology 109, 1805–1810 (1981).

  29. 29.

    & Science 181, 177–179 (1973).

  30. 30.

    Science 182, 177–179 (1973).

  31. 31.

    & Neuroendocrinology 28, 155–159 (1979).

  32. 32.

    , , & Acta endocr. 89, 1–9 (1978).

  33. 33.

    & Endocrinology 106, 867–870 (1980).

  34. 34.

    & Endocrinology 107, 1782–1790 (1980).

  35. 35.

    , , & Nature 274, 281–282 (1978).

  36. 36.

    , , , & Neuroendocrinology 32, 163–167 (1981).

  37. 37.

    , , , & Nature 294, 757–759 (1981).

  38. 38.

    , & A Stereotaxic Atlas of the Rat Brain (Plenum, New York, 1979).

  39. 39.

    , & Endocrinology 110, 1116–1123 (1982).

Download references

Author information

Author notes

    • H. M. Fraser

    Medical Research Council, Reproductive Biology Unit, Centre for Reproductive Biology, Edinburgh EH3 9EW, UK

Affiliations

  1. Neuroendocrine Research Unit, Animal Physiology Division, Agricultural Research Council, Meat Research Institute, Langford, Bristol BS18 7DY, UK

    • D. J. S. Sirinathsinghji
    • , P. E. Whittington
    • , A. Audsley
    •  & H. M. Fraser

Authors

  1. Search for D. J. S. Sirinathsinghji in:

  2. Search for P. E. Whittington in:

  3. Search for A. Audsley in:

  4. Search for H. M. Fraser in:

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/301062a0

Further reading Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.