The roles of individual polyoma virus early proteins in oncogenic transformation

Abstract

The expression in normal rat cells of modified polyoma virus genomes, separately encoding large T, middle T or small T antigens, has allowed the investigation of the roles of these proteins in oncogenic transformation. Middle T is sufficient to transform cells of established lines but the transformants are serum dependent. Large T lacks intrinsic oncogenic potential but can relieve the serum dependence of normal and transformed cells. Middle T alone cannot transform primary rat embryo fibroblasts.

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Rassoulzadegan, M., Cowie, A., Carr, A. et al. The roles of individual polyoma virus early proteins in oncogenic transformation. Nature 300, 713–718 (1982). https://doi.org/10.1038/300713a0

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