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The roles of individual polyoma virus early proteins in oncogenic transformation

Abstract

The expression in normal rat cells of modified polyoma virus genomes, separately encoding large T, middle T or small T antigens, has allowed the investigation of the roles of these proteins in oncogenic transformation. Middle T is sufficient to transform cells of established lines but the transformants are serum dependent. Large T lacks intrinsic oncogenic potential but can relieve the serum dependence of normal and transformed cells. Middle T alone cannot transform primary rat embryo fibroblasts.

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References

  1. Ito, Y., Spurr, N. & Dulbecco, R. Proc. natn. Acad. Sci. U.S.A. 74, 1259–1263 (1977).

    Article  ADS  CAS  Google Scholar 

  2. Huntchinson, M. A., Hunter, T. & Eckhart, W. Cell 15, 65–80 (1978).

    Article  Google Scholar 

  3. Hunter, T., Huntchinson, M. A. & Eckhart, W. Proc. natn. Acad. Sci. U.S.A. 75, 5917–5920 (1978).

    Article  ADS  CAS  Google Scholar 

  4. Schaffhausen, B. S., Silver, J. E. & Benjamin, T. Proc. natn. Acad. Sci. U.S.A. 75, 79–83 (1978).

    Article  ADS  CAS  Google Scholar 

  5. Ito, Y. in Viral Oncology (ed. Klein, G.) 447–473 (Raven, New York, 1980).

    Google Scholar 

  6. Türler, H. Molec. cell. Biochem. 32, 63–93 (1980).

    Article  PubMed  Google Scholar 

  7. Hand, R. Biochim. biophys. Acta 651, 1–24 (1981).

    CAS  PubMed  Google Scholar 

  8. Triesman, R., Novak, U., Favaloro, J. & Kamen, R. Nature 292, 595–600 (1981).

    Article  ADS  Google Scholar 

  9. Tyndall, C., La Mantia, G., Thacker, C. M., Favaloro, J. & Kamen, R. Nucleic Acids Res. 9, 6231–6250 (1981).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Rassoulzadegan, M. et al. in 35th M.D. Anderson Hospital and Tumor Inst. Symp. Fundamental Cancer Research (Raven, New York, in the press).

  11. Treisman, R. H., Cowie, A., Favaloro, J. M., Jat, P. & Kamen, R. J. molec. appl. Genet. 1, 83–92 (1981).

    CAS  Google Scholar 

  12. Israel, M. A., Simmons, D. T., Hourihan, S. L., Rowe, W. P. & Martin, M. A. Proc. natn. Acad. Sci. U.S.A. 76, 3713–3716 (1979).

    Article  ADS  CAS  Google Scholar 

  13. Hassell, J. A., Topp, W. C., Rifkin, D. B. & Moreau, P. E. Proc. natn. Acad. Sci. U.S.A. 77, 3978–3982 (1980).

    Article  ADS  CAS  Google Scholar 

  14. Ito, Y. & Spurr, N. Cold Spring Harb. Symp. quant. Biol. 44, 149–147 (1980).

    Article  CAS  PubMed  Google Scholar 

  15. Ito, Y., Spurr, N. & Griffin, B. E. J. Virol. 35, 219–227 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Lania, L. et al. Virology 101, 217–227 (1980).

    Article  CAS  PubMed  Google Scholar 

  17. Novack, U., Dilworth, S. M. & Griffin, B. E. Proc. natn. Acad. Sci. U.S.A. 77, 3278–3282 (1980).

    Article  ADS  Google Scholar 

  18. Templeton, D. & Eckhart, W. J. Virol. 41, 1014–1024 (1981).

    Google Scholar 

  19. Silver, J., Schaffhausen, B. & Benjamin, T. Cell 15, 485–496 (1978).

    Article  CAS  PubMed  Google Scholar 

  20. Staneloni, R., Fluck, M. & Benjamin, T. Virology 77, 598–609 (1977).

    Article  CAS  PubMed  Google Scholar 

  21. Rassoulzadegan, M., Gaudray, P., Canning, M., Trejo-Avila, L. & Cuzin, F. Virology 114, 489–500 (1981).

    Article  CAS  PubMed  Google Scholar 

  22. Todaro, G. J. & Green, H. J. Cell Biol. 17, 299–310 (1963).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Seif, R. & Cuzin, F. J. Virol. 24, 721–728 (1977).

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Rassoulzadegan, M., Binétruy, B. & Cuzin, F. Nature 295, 257–259 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  25. Benjamin, T. L. Proc. natn. Acad. Sci. U.S.A. 73, 1097–1100 (1970).

    Google Scholar 

  26. Hattori, J., Carmichael, G. G. & Benjamin, T. L. Cell 16, 505–513 (1979).

    Article  CAS  PubMed  Google Scholar 

  27. Lania, L., Griffiths, M., Cooke, B., Ito, Y. & Fried, M. Cell 18, 793–802 (1979).

    Article  CAS  PubMed  Google Scholar 

  28. Kaplan, P. & Ozanne, B. Virology (in the press).

  29. Smith, H. S., Scher, C. D. & Todaro, G. J. Virology 44, 359–370 (1971).

    Article  CAS  PubMed  Google Scholar 

  30. Vogt, M. & Dulbecco, R. Proc. natn. Acad. Sci. U.S.A. 49, 171–179 (1963).

    Article  ADS  CAS  Google Scholar 

  31. Rassoulzadegan, M. et al. Cold Spring Harb. Symp. quant. Biol. 44, 333–342 (1980).

    Article  CAS  PubMed  Google Scholar 

  32. Della Valle, G., Fenton, R. G. & Basilico, F. Cell 23, 347–355 (1981).

    Article  CAS  PubMed  Google Scholar 

  33. Martin, R. G. et al. Cold Spring Harb. Symp. quant. Biol. 44, 311–324 (1980).

    Article  CAS  PubMed  Google Scholar 

  34. Lehman, I. R. & Uyemura, D. G. Science 193, 963–969 (1976).

    Article  ADS  CAS  PubMed  Google Scholar 

  35. Griffin, B. E. & Maddock, C. J. Virol. 31, 645–656 (1979).

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Medina, D. in Cancer, a Comprehensive Treatise Vol. 3 (ed. Becker, F. F.) 99–120 (Plenum, New York, 1975).

    Google Scholar 

  37. Soeda, E., Arrand, J. R., Smolar, N., Walsh, J. E. & Griffin, B. E. Nature 283, 445–453 (1980).

    Article  ADS  CAS  PubMed  Google Scholar 

  38. Pollack, R., Risser, R., Conlon, S. & Rifkin, D. Proc. natn. Acad. Sci. U.S.A. 71, 4792–4796 (1974).

    Article  ADS  CAS  Google Scholar 

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Rassoulzadegan, M., Cowie, A., Carr, A. et al. The roles of individual polyoma virus early proteins in oncogenic transformation. Nature 300, 713–718 (1982). https://doi.org/10.1038/300713a0

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