Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Nonspecific inhibitor released by T acceptor cells reduces the production of interleukin-2

Abstract

Mice exposed to contact sensitizing agents such as oxazolone (ox) or picryl (pic) derivatives develop specific immunological suppression to these substances which results from the activation of a circuit of T suppressor cells1–3. However, one of the final immunological events in the T suppressor cell circuit is the release of a nonspecific, H–2 unrestricted inhibitor by I–J+, Lyt-2+ cyclophosphamide-sensitive T acceptor cells (Tacc)3–7'. This nonspecific inhibitor (nsINH) can block the passive transfer of contact sensitivity and depress DNA synthesis by lymphocytes exposed to mitogens and alloantigens but the molecular mechanism is poorly understood. We provide evicence here that the production of interleukin-2 (IL-2)8–15 by stimulated lymphoid cells is suppressed when the cells have been exposed to nsINH.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Claman, H. N., Miller, S. D., Sy, M.-S. & Moorhead, J. W. Immun. Rev. 50, 105–132 (1980).

    Article  CAS  Google Scholar 

  2. Germain, R. N. & Benacerraf, B. Scand. J. Immun. 13, 1–10 (1981).

    Article  Google Scholar 

  3. Asherson, G. L., Zembala, M., Colizzi, V. & Malkovsky, M. Lymphokines (ed. Pick, E.) (Academic, New York, in the press).

  4. Asherson, G. L. & Zembala, M. Ann. N. Y. Acad. Sci. 392, 71–88 (1982).

    Article  ADS  CAS  Google Scholar 

  5. Zembala, M., Asherson, G. L. & Colizzi, V. Nature 297, 411–413 (1982).

    Article  ADS  CAS  Google Scholar 

  6. Zembala, M., Asherson, G. L., James, B., Stein, V. & Watkins, M. C. J. Immun. (in the press).

  7. Malkovsky, M., Asherson, G. L., Chandler, P., Colizzi, V., Watkins, M. C. & Zembala, M. J. Immun. (in the press).

  8. Morgan, D. A., Ruscetti, F. W. & Gallo, R. Science 193, 1007–1008 (1976).

    Article  ADS  CAS  Google Scholar 

  9. Gillis, S. & Smith, K. A. Nature 268, 154–156 (1977).

    Article  ADS  CAS  Google Scholar 

  10. Wagner, H. et al. Immun. Rev. 51, 215–255 (1980).

    Article  CAS  Google Scholar 

  11. Watson, J. & Mochizuki, D. Immun. Rev. 51, 257–278 (1980).

    Article  CAS  Google Scholar 

  12. Smith, K. A. Immun. Rev. 51, 337–357 (1980).

    Article  CAS  Google Scholar 

  13. Farrar, W. L., Johnson, H. M. & Farrar, J. J. J. Immun. 126, 1120–1125 (1981).

    CAS  Google Scholar 

  14. Granelli-Piperno, A., Vassalli, J.-D. & Reich, E. J. exp. Med. 154, 422–431 (1981).

    Article  CAS  Google Scholar 

  15. Cheever, M. A., Greenberg, P. D., Fefer, A. & Gillis, S. J. exp. Med. 155, 968–980 (1982).

    Article  CAS  Google Scholar 

  16. Wagner, H. & Röllinghoff, M. J. exp. Med. 148, 1523–1538 (1978).

    Article  CAS  Google Scholar 

  17. Hardt, C., Röllinghoff, M., Pfizenmaier, K., Mosmann, H. & Wagner, H. J. exp. Med. 154, 262–274 (1981).

    Article  CAS  Google Scholar 

  18. Watson, J., Gillis, S., Marbrook, J., Mochizuki, D. & Smith, K. A. J. exp. Med. 150, 849–861 (1979).

    Article  CAS  Google Scholar 

  19. Goldsby, R. A., Osborne, B. A., Simpson, E. & Herzenberg, L. A. Nature 267, 707–708 (1977).

    Article  ADS  CAS  Google Scholar 

  20. Gorer, P. A. & Amos, D. B. Cancer Res. 16, 338–343 (1956).

    CAS  PubMed  Google Scholar 

  21. Köhler, G., Howe, S. C. & Milstein, C. Eur. J. Immun. 6, 292–295 (1976).

    Article  Google Scholar 

  22. Raulet, D. H. & Bevan, M. J. Nature 296, 754–757 (1982).

    Article  ADS  CAS  Google Scholar 

  23. Wagner, H. et al. J. exp. Med. 155, 1876–1881 (1982).

    Article  CAS  Google Scholar 

  24. Asherson, G. L. & Zembala, M. Immunology 42, 1005–1013 (1980).

    Google Scholar 

  25. Julius, M. H., Simpson, E. & Herzenberg, L. A. Eur. J. Immun. 3, 645–649 (1973).

    Article  CAS  Google Scholar 

  26. Shearer, G. M. Eur. J. Immun. 4, 527–533 (1974).

    Article  CAS  Google Scholar 

  27. Boyle, W. Transplantation 6, 761–764 (1968).

    Article  CAS  Google Scholar 

  28. Parish, C. R., Kirov, S. M., Bowern, N. & Blanden, R. V. Eur. J. Immun. 4, 808–815 (1974).

    Article  Google Scholar 

  29. Dunn, T. B. & Potter, M. J. natn. Cancer Inst. 18, 587–595 (1957).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Malkovsky, M., Asherson, G., Stockinger, B. et al. Nonspecific inhibitor released by T acceptor cells reduces the production of interleukin-2. Nature 300, 652–655 (1982). https://doi.org/10.1038/300652a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/300652a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing