Nonspecific inhibitor released by T acceptor cells reduces the production of interleukin-2

Abstract

Mice exposed to contact sensitizing agents such as oxazolone (ox) or picryl (pic) derivatives develop specific immunological suppression to these substances which results from the activation of a circuit of T suppressor cells1–3. However, one of the final immunological events in the T suppressor cell circuit is the release of a nonspecific, H–2 unrestricted inhibitor by I–J+, Lyt-2+ cyclophosphamide-sensitive T acceptor cells (Tacc)3–7'. This nonspecific inhibitor (nsINH) can block the passive transfer of contact sensitivity and depress DNA synthesis by lymphocytes exposed to mitogens and alloantigens but the molecular mechanism is poorly understood. We provide evicence here that the production of interleukin-2 (IL-2)8–15 by stimulated lymphoid cells is suppressed when the cells have been exposed to nsINH.

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Malkovsky, M., Asherson, G., Stockinger, B. et al. Nonspecific inhibitor released by T acceptor cells reduces the production of interleukin-2. Nature 300, 652–655 (1982). https://doi.org/10.1038/300652a0

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