Abstract
The cellular oncogene c-mos is rearranged in a mouse myeloma and the tumour mRNA contains transcripts hybridizing with a v-mos probe. The rearranged gene (rc-mos) was cloned in λ phage and shown to transform mouse fibroblasts in transfection assays. rc-mos differs from its progenitor, c-mos, only at the 5′ end of the gene, where c-mos sequences have been substituted by a novel cellular DNA fragment. This fragment contains a 159-base pair (bp) insertion sequence (IS)-like element localized immediately 5′ to the junction with c-mos. This is the first demonstration in a non-virally-induced tumour of activation of a cellular oncogene by a mechanism possibly involving DNA transposition.
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References
Cold Spring Harb. Symp. quant. Biol. 44 (1980).
Bishop, J. M. Cell 23, 5–6 (1981).
Coffin, J. M. et al. J. Virol. 40, 953–957 (1981).
Stehelin, D., Varmus, H. E., Bishop, J. M. & Vogt, P. K. Nature 260, 170–173 (1976).
Shilo, B.-Z. & Weinberg, R. A. Proc. natn. Acad. Sci. U.S.A. 78, 6789–6792 (1981).
Hayward, W. S., Neel, G. B. & Astrin, S. M. Nature 290, 475–480 (1981).
Payne, G. S. et al. Cell 23, 311–322 (1981).
Shih, C. et al. Proc. natn. Acad. Sci. U.S.A. 76, 5714–5718 (1979).
Shih, C. et al. Nature 290, 261–264 (1981).
Lane, M. A., Sainten, A. & Cooper, G. M. Proc. natn. Acad. Sci. U.S.A. 78, 5185–5189 (1981).
Lane, M. A., Sainten, A. & Cooper, G. M. Cell 28, 873–880 (1982).
Hopkins, N. et al. Proc. natn. Acad. Sci. U.S.A. 78, 7555–7559 (1981).
Kronitis, T. G. & Cooper, G. M. Proc. natn. Acad. Sci. U.S.A. 78, 1181–1184 (1981).
Perucho, M. et al. Cell 27, 467–476 (1981).
Pulciani, S. et al. Proc. natn. Acad. Sci. U.S.A. 79, 2845–2849 (1982).
Murray, M. J. et al. Cell 25, 355–361 (1981).
Der, C. J., Krontiris, T. G. & Cooper, G. M. Proc. natn. Acad. Sci. U.S.A. 79, 3637–3640 (1982).
Parada, L. F., Tabin, C. J., Shih, C. & Weinberg, R. A. Nature 297, 474–478 (1982).
Santos, E., Tronick, S. R., Aaronson, S. A., Pulciani, S. & Barbacid, M. Nature 298, 343–347 (1982).
Cairns, J. Nature 289, 353–357 (1981).
Klein, G. Nature 294, 313–318 (1981).
Frankel, A. E. & Fischinger, P. J. Proc. natn. Acad. Sci. U.S.A. 73, 3705–3709 (1976).
Canaani, E., Robbins, K. C. & Aaronson, S. A. Nature 282, 378–383 (1979).
Andersson, P., Goldfarb, M. P. & Weinberg, R. A. Cell 16, 63–75 (1979).
Oskarsson, M. et al. Science 207, 1222–1224 (1980).
Reddy, E. P. et al. Proc. natn. Acad. Sci. U.S.A. 77, 5234–5238 (1980).
Van Beveren, J. et al. Cell 27, 97–108 (1981).
Papkoff, J., Verma, I. M. & Hunter, T. Cell 29, 417–426 (1982).
Blattner, F. R. et al. Science 196, 161–169 (1977).
Watson, R., Oskarsson, M. & Vande Woude, G. F. Proc. natn. Acad. Sci. U.S.A. 79, 4078–4082 (1982).
Farabough, P. J. & Fink, G. R. Nature 286, 352–356 (1980).
Gafner, J. & Philippsen, P. Nature 286, 414–418 (1980).
Dunsmuir, P. et al. Cell 21, 575–579 (1980).
Allet, B. Cell 16, 123–129 (1979).
Kahaman, R. & Kamp, D. Nature 280, 247–250 (1979).
Shimotohno, K., Mizutani, S. & Temin, H. M. Nature 285, 550–554 (1980).
Majors, J. E. & Varmus, H. E. Nature 289, 253–258 (1980).
Dhar, R. et al. Proc. natn. Acad. Sci. U.S.A. 77, 3937–3941 (1980).
Spector, D. et al. Cell 13, 371–379 (1978).
Langebeheim, H., Shih, T. Y. & Scolnick, E. M. Virology 106, 292–300 (1980).
Witte, O. N., Rosenberg, N. E. & Baltimore, D. Nature 281, 396–398 (1979).
Eva, A. et al. Nature 295, 116–119 (1982).
Gattoni, S. et al. Molec. cell. Biol. 2, 42–51 (1982).
Calos, M. P. & Miller, J. H. Cell 20, 579–595 (1980).
Kleckner, N. A. Rev. Genet. 15, 341–404 (1981).
Cameron, J. C., Loh, E. Y. & Davis, R. W. Cell 16, 735–751 (1979).
Canaani, E. & Aaronson, S. A. Proc. natn. Acad. Sci. U.S.A. 76, 1677–1681 (1979).
Saedler, H. et al. Molec. gen. Genet. 132, 269–289 (1974).
Graham, F. L. & Van Der Eb, A. J. Virology 52, 456–467 (1973).
Vogelstein, B. & Gillespie, D. Proc. natn. Acad. Sci. U.S.A. 76, 615–619 (1979).
Maxam, A. M. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 74, 560–564 (1977).
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Rechavi, G., Givol, D. & Canaani, E. Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like element. Nature 300, 607–611 (1982). https://doi.org/10.1038/300607a0
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DOI: https://doi.org/10.1038/300607a0
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