The T lymphocyte antigen receptor—paradigm lost

Abstract

It has been dogma that the antigen receptors on T lymphocytes must have recognition sites that are essentially the same as those of antibodies and that the receptors would be found if structures related to immunoglobulin V-domains could be identified on T lymphocytes. In a critical assessment we conclude that there is no sound basis for these views.

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Jensenius, J., Williams, A. The T lymphocyte antigen receptor—paradigm lost. Nature 300, 583–588 (1982). https://doi.org/10.1038/300583a0

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