Abstract
In the preceding paper1, cytological evidence is presented to show that in ‘sex-reversed’ XX male mice2 the sex-reversing factor, Sxr, is carried on a dark-staining body located on the distal end of the paternal X chromosome. The X-chromosomal location of Sxr raises the possibility that it may be subject to the X chromosome inactivation process3. However, the regular segregation of Sxr and the absence of any indication that intersexes occur with a higher than normal frequency in Sxr stocks4 suggests that either inactivation of Sxr does not occur, or, if it does, that the proportion of cells with the Sxr-bearing X genetically active is sufficient to ensure normal testicular differentiation. Here we present information on the sexual development of chromosomally XX mice carrying Sxr in which the Sxr-bearing X chromosome is held in the inactive condition in most if not all somatic cells by use of the T(X; 16)16H (T16H) X-autosome translocated chromosome5–10 Mice of this genotype were found to develop as normal but sterile males, normal fertile females or intersexes.
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References
Evans, E. P., Burtenshaw, M. & Cattanach, B. M. Nature 300, 443–445 (1982).
Cattanach, B. M., Pollard, C. E. & Hawkes, S. G. Cytogenetics 10, 318–337 (1971).
Lyon, M. F. Nature 190, 372–373 (1961).
Lyon, M. F., Cattanach, B. M. & Charlton, H. in Mechanisms of Sex Determination in Animals and Man (eds Austin, C. R. & Edwards, R. G.) 329–386 (Academic, New York, 1981).
Lyon, M. F. et al. Cytogenetics 3, 306–323 (1964).
Eicher, E. M. in Prospects for Sexing Mammalian Sperm (eds Amann, C. R. & Seidell, G. E.) (Colorado University Press, 1982).
Ohno, S. & Lyon, M. F. Chromosoma 16, 90–100 (1965).
Russell, L. B. & Cachiero, N. L. A. in Genetic Mosaics and Chimeras in Mammals Basic Life Sciences, Vol. 12 (ed. Russell, L. B.) 393–416 (Plenum, New York, 1978).
Tagaki, N. Chromosoma 81, 439–459 (1980).
Disteche, C. M., Eicher, E. M. & Latt, S. A. Expl Cell Res. 133, 357–362 (1981).
McLaren, A. & Monk, M. Nature 300, 446–448 (1982).
Gartler, S. M., Andina, R. & Gant, N. Expl Cell Res. 91, 454–457 (1975).
Johnston, P. G. Genet. Res. 37, 312–322 (1981).
Evans, E. P., Ford, C. E. & Lyon, M. F. Nature 267, 430–431 (1977).
Cattanach, B. M. Genet. Res. 23, 291–306 (1974).
Cattanach, B. M. A. Rev. Genet. 9, 1–18 (1975).
Eicher, E. M. Adv. Genet. 15, 175–259 (1970).
Ohno, S. Cell 7, 315–321 (1976).
Johnston, P. & Cattanach, B. M. Genet. Res. 37, 151–160 (1981).
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Cattanach, B., Evans, E., Burtenshaw, M. et al. Male, female and intersex development in mice of identical chromosome constitution. Nature 300, 445–446 (1982). https://doi.org/10.1038/300445a0
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DOI: https://doi.org/10.1038/300445a0
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