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Analysis of discrimination mechanisms in the mammalian olfactory system using a model nose

Abstract

Olfaction exhibits both high sensitivity for odours and high discrimination between them1. We suggest that to make fine discriminations between complex odorant mixtures containing varying ratios of odorants without the necessity for highly specialized peripheral receptors, the olfactory systems makes use of feature detection using broadly tuned receptor cells organized in a convergent neurone pathway. As a test of this hypothesis we have constructed an electronic nose using semiconductor transducers and incorporating design features suggested by our proposal. We report here that this device can reproducibly discriminate between a wide variety of odours, and its properties show that discrimination in an olfactory system could be achieved without the use of highly specific receptors.

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References

  1. 1

    Stoddart, D. M. (ed.) Symp. zool. Soc., Lond. 45, (1980).

  2. 2

    Dodd, G. H. & Squirrell, D. J. Symp. Zool. Soc., Lond. 45, 35–56 (1980).

    Google Scholar 

  3. 3

    Dodd, G. H. & Persaud, K. in Biochemistry of Taste and Olfaction (eds Cagan, R. & Kare, M.) 333–357 (Academic, New York, 1981).

    Book  Google Scholar 

  4. 4

    Holden, A. V. Lect. Notes Biomath. 32 (Springer, Heidelberg, 1976).

    Google Scholar 

  5. 5

    Sampson, J. R. Adaptive Information Processing (Springer, Berlin, 1976).

    Book  Google Scholar 

  6. 6

    Uttal, W. R. The Psychobiology of Sensory Coding (Harper & Row, New York, 1973).

    Google Scholar 

  7. 7

    Deutsch, S. Models of the Nervous System (Wiley, New York, 1967).

    Google Scholar 

  8. 8

    Cherry, R. J., Dodd, G. H. & Chapman, D. Biochim. biophys. Acta 211, 409–416 (1970).

    CAS  Article  Google Scholar 

  9. 9

    Wilkens, W. F., Hartman, J. D. & Rosano, H. Ann. N.Y. Acad. Sci. 116, 608–612 (1964).

    ADS  CAS  Article  Google Scholar 

  10. 10

    Moncrieff, R. W. J. appl. Physiol. 16, 742–749 (1961).

    CAS  Article  Google Scholar 

  11. 11

    Dravnieks, A. & Trotter, P. J. J. Scient. Instrum. 42, 624–627 (1965).

    ADS  CAS  Article  Google Scholar 

  12. 12

    Sawateri, K. Chem. Abstr. 83, P 35757 T (1975).

  13. 13

    Tanyolac, N. N. & Eaton, J. R. J. Am. pharmac. Ass. 39, 10–14 (1950).

    Article  Google Scholar 

  14. 14

    Persaud, K., Pelosi, P. & Dodd, G. H. Olfaction & Taste 7, 101 (1980).

    Google Scholar 

  15. 15

    Ohno, Y. Chem. Abstr. 85, 28276Y (1976).

  16. 16

    T.G.S. Gas-Sensing Semi-Conductor (Figaro Engineering Inc., Osaka, 1974).

  17. 17

    Dodd, G. H. & Persaud, K. C. Provisional UK Patent No. 8035806 (1980).

  18. 18

    Electronics Today International 62–65 (January 1979).

  19. 19

    Roberts, G. G., Pande, K. P. & Barlow, W. A. Electron. Lett. 13, 581–583 (1977).

    CAS  Article  Google Scholar 

  20. 20

    Persaud, K., Wood, P., Squirrell, D. J. & Dodd, G. H. Biochem. Soc. Trans. 9, 107–108 (1981).

    CAS  Article  Google Scholar 

  21. 21

    Menevse, A., Dodd, G. H. & Poynder, T. M. Biochem. J. 176, 845–854 (1978).

    CAS  Article  Google Scholar 

  22. 22

    Squirrell, D. J. thesis, Univ. Warwick, UK (1978).

Download references

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Persaud, K., Dodd, G. Analysis of discrimination mechanisms in the mammalian olfactory system using a model nose. Nature 299, 352–355 (1982). https://doi.org/10.1038/299352a0

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