Abstract
Membrane Ca2+ currents are the triggers for numerous cellular activities such as secretion, contraction, and oscillations in neural discharge. Different Ca2+ channels are assumed to subserve the various functions1; this does not apply to Na+ currents for which there is thought to be only one type of channel. We have examined single Ca2+ channels in cells from three very different species (bird, snail and rat) using the patch-clamp method2, and report here that unitary events consisted of small, brief current pulses that often occurred in bursts and were similar for all three species. Thus, reported differences among various Ca2+ currents1 must have other origins.
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References
Hagiwara, S. & Byerly, L. A. Rev. Neurosci. 4, 69–125 (1981).
Hamill, O. P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F. J. Pflügers Arch. ges. Physiol. 391, 85–100 (1981).
Hofmeier, G. & Lux, H. D. Pflügers Arch. ges. Physiol. 391, 242–251 (1981).
Dunlap, K. & Fischbach, G. D. J. Physiol., Lond. 317, 519–535 (1981).
Greene, L. A. & Tischler, A. S. Proc. natn. Acad. Sci. U.S.A. 73, 2424–2428 (1976).
O'Lague, P. H. & Huttner, S. L. Proc. natn. Acad. Sci. U.S.A. 77, 1701–1705 (1980).
Brown, A. M., Morimoto, K., Tsuda, Y. & Wilson, D. L. J. Physiol., Lond. 320, 193–218 (1981).
Barde, Y. A., Edgar, D. & Thoenen, H. Proc. natn. Acad. Sci. U.S.A. 77, 1199–1203 (1980).
Lucas, C. A., Edgar, D. & Thoenen, H. Expl Cell Res. 121, 79–86 (1979).
Lux, H. D. & Nagy, K. Pflügers Arch. ges. Physiol. 391, 252–254 (1981).
Spector, I. in Excitable Cells in Tissue Culture (eds Nelson, P. G. & Lieberman, M.) 247–274 (Plenum, New York, 1981).
Kostyuk, P. C., Veselovsky, N. S. & Tsyndrenko, A. Y. Neuroscience 6, 2423–2430 (1981).
Akaike, N., Fishman, H. M., Lee, K. S., Moore, L. C. & Brown, A. M. Nature 274, 379–382 (1978).
Krishtal, O. A., Pidoplichko, V. I. & Shakhovalov, Yu. A. J. Physiol., Lond. 310, 423–434 (1981).
Kostyuk, P. G., Krishtal, O. A. & Shakhovalov, Yu. A. J. Physiol., Lond. 270, 545–568 (1977).
Tsuda, Y., Wilson, D. L. & Brown, A. M. Biophys. J. 37, 181a (1982).
Fenwick, E. M., Marty, A. & Neher, E. J. Physiol., Lond. (in the press).
Colquhoun, D. & Hawkes, A. G. Proc. R. Soc. B211, 205–235 (1981).
Reuter, H., Stevens, C. F., Tsien, R. & Yellen, G. Nature 297, 501–503 (1982).
Yatani, A., Tsuda, Y., Akaika, N. & Brown, A. M. Nature 296, 169–171 (1982).
Rasmussen, H. & Goodman, D. B. P. Physiol. Rev. 57, 421–509 (1977).
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Brown, A., Camerer, H., Kunze, D. et al. Similarity of unitary Ca2+ currents in three different species. Nature 299, 156–158 (1982). https://doi.org/10.1038/299156a0
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DOI: https://doi.org/10.1038/299156a0
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