Abstract
The in vitro growth of immature erythroid precursors, assayed as burst forming units (BFU–E), can be enhanced by co-culturing with normal T cells1–3. The growth enhancing effect of normal T cells, however, was shown to be the outcome of at least two functionally distinct subpopulations, one that enhances burst formation and one that limits it3,4. It appears that the T cell population limiting growth enhancement of the erythroid precursors expresses ‘Ia-like’ antigen (Ia+) because treatment of T cells with anti-Ia antibody and complement significantly increased the ability of the remaining T cells to stimulate antologous BFU–E growth3. As BFU–E also seem to express Ia, the inhibiting effect of certain T cells on BFU–E growth may involve the Ia molecule. We show here that the inhibitory effect of Ia+ T cells on BFU–E growth is genetically restricted to cell combinations which are phenotypically identical for at least one HLA–DR (Ia-like) antigen.
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Torok-Storb, B., Hansen, J. Modulation of in vitro BFU–E growth by normal Ia-positive T cells is restricted by HLA–DR. Nature 298, 473–474 (1982). https://doi.org/10.1038/298473a0
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DOI: https://doi.org/10.1038/298473a0
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