Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Are the Lsh and Ity disease resistance genes at one locus on mouse chromosome 1?

Abstract

Ity, a gene controlling natural resistance to Salmonella typhimurium infection1,2, and Lsh, which controls innate resistance to Leishmania donovani infection3, are both located on chromosome 1 of the mouse4,5 and it has been suggested6 that they might be identical. O'Brien et al.7 examined salmonella resistance in recombinant inbred (RI) strains of mice, and observed discordant responses in three strains (BXD-18, BXD-20, BXD-29) from one progenitor strain combination (C57BL/6J × DBA/2J) when compared with the published Lsh typing5. On the basis of this and additional information on salmonella resistance in (C57BL/6J × BXD-18)F1 and [(C57BL/6J × DBA/2J) × BXD-29] backcross mice, it was concluded that Ity and Lsh are closely linked but distinct genetic loci. We have now re-examined both leishmania and salmonella resistance in larger numbers of these putative recombinant strains and in various hybrid and backcross generations, and our results indicate that BXD-18 and BXD-20 retype as Lshs and BXD-29 as Itys. Hence there is no longer any discordance between Lsh and Ity typings for the RI strains. The results do, however, suggest additional modifying genetic control of salmonella resistance in BXD strains involving at least two other genetic loci. There is therefore no clear evidence to demonstrate that Ity and Lsh are not the same genetic locus.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Plant, J. & Glynn, A. A. Nature 248, 345–347 (1974).

    Article  ADS  CAS  Google Scholar 

  2. Plant, J. & Glynn, A. A. J. infect. Dis. 133, 72–78 (1976).

    Article  CAS  Google Scholar 

  3. Bradley, D. J. Clin. exp. Immun. 30, 130–140 (1977).

    CAS  PubMed  Google Scholar 

  4. Plant, J. & Glynn, A. A. Clin. exp. Immun. 37, 1–6 (1979).

    CAS  PubMed  Google Scholar 

  5. Bradley, D. J., Taylor, B. A., Blackwell, J., Evans, E. P. & Freeman, J. Clin. exp. Immun. 37, 7–14 (1979).

    CAS  PubMed  Google Scholar 

  6. Bradley, D. J. Nature 250, 353 (1974).

    Article  ADS  CAS  Google Scholar 

  7. O'Brien, A. D., Rosenstreich, D. L. & Taylor, B. A. Nature 287, 440–442 (1980).

    Article  ADS  CAS  Google Scholar 

  8. Hormaeche, C. E. Immunology 37, 319–327 (1979).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Benjamin, W. H. & Briles, D. E. Abstr. an. Meet. Am. Soc. for Microbiol. No. E51, 63 Texas (1981).

    Google Scholar 

  10. Skamene, E. et al. Nature 297, 506–509 (1982).

    Article  ADS  CAS  Google Scholar 

  11. Gros, P., Skamene, E. & Forget, A. J. Immun. 127, 2417–2421 (1981).

    CAS  PubMed  Google Scholar 

  12. Bradley, D. J. & Kirkley, J. Clin. exp. Immun. 30, 119–129 (1979).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Plant, J., Blackwell, J., O'Brien, A. et al. Are the Lsh and Ity disease resistance genes at one locus on mouse chromosome 1?. Nature 297, 510–511 (1982). https://doi.org/10.1038/297510a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/297510a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing