Abstract
Ity, a gene controlling natural resistance to Salmonella typhimurium infection1,2, and Lsh, which controls innate resistance to Leishmania donovani infection3, are both located on chromosome 1 of the mouse4,5 and it has been suggested6 that they might be identical. O'Brien et al.7 examined salmonella resistance in recombinant inbred (RI) strains of mice, and observed discordant responses in three strains (BXD-18, BXD-20, BXD-29) from one progenitor strain combination (C57BL/6J × DBA/2J) when compared with the published Lsh typing5. On the basis of this and additional information on salmonella resistance in (C57BL/6J × BXD-18)F1 and [(C57BL/6J × DBA/2J) × BXD-29] backcross mice, it was concluded that Ity and Lsh are closely linked but distinct genetic loci. We have now re-examined both leishmania and salmonella resistance in larger numbers of these putative recombinant strains and in various hybrid and backcross generations, and our results indicate that BXD-18 and BXD-20 retype as Lshs and BXD-29 as Itys. Hence there is no longer any discordance between Lsh and Ity typings for the RI strains. The results do, however, suggest additional modifying genetic control of salmonella resistance in BXD strains involving at least two other genetic loci. There is therefore no clear evidence to demonstrate that Ity and Lsh are not the same genetic locus.
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References
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Plant, J., Blackwell, J., O'Brien, A. et al. Are the Lsh and Ity disease resistance genes at one locus on mouse chromosome 1?. Nature 297, 510–511 (1982). https://doi.org/10.1038/297510a0
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DOI: https://doi.org/10.1038/297510a0
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