Article | Published:

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene

Nature volume 297, pages 474478 (10 June 1982) | Download Citation

Subjects

Abstract

Examination of homologies between retroviral oncogenes and transforming sequences defined by transfection reveals that the human bladder carcinoma (EJ) oncogene is homologous to the Harvey sarcoma virus oncogene (ras). Structural analysis limits the region of homology to a 3.0-kilobase SacI fragment of the EJ oncogene. Both EJ and ras DNA probes detect similar transcripts in transfectants derived from bladder carcinoma cell lines.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , & Proc. natn. Acad. Sci. U.S.A. 75, 4102–4106 (1978).

  2. 2.

    , , & Nature 260, 170–173 (1976).

  3. 3.

    Klein, G. (ed.) Advances in Viral Oncology: Cell Derived Oncogenes (Raven, New York, 1981).

  4. 4.

    et al. J. Virol. 40, 953–957 (1981).

  5. 5.

    & Proc. natn. Acad. Sci. U.S.A. 78, 6789–6792 (1981).

  6. 6.

    , , , & Proc. natn. Acad. Sci. U.S.A. 76, 5714–5718 (1979).

  7. 7.

    , , & Nature 290, 261–264 (1981).

  8. 8.

    , , & Proc. natn. Acad. Sci. U.S.A. 78, 7555–7559 (1981).

  9. 9.

    , & Proc. natn. Acad. Sci. U.S.A. 78, 5185–5189 (1981).

  10. 10.

    et al. Cell 25, 355–361 (1981).

  11. 11.

    & Proc. natn. Acad. Sci. U.S.A. 78, 1181–1184 (1981).

  12. 12.

    et al. Cell 27, 467–476 (1981).

  13. 13.

    J. molec. Biol. 98, 503–517 (1975).

  14. 14.

    & Nature 289, 607–609 (1981).

  15. 15.

    , , & Cell 22, 777–785 (1980).

  16. 16.

    et al. Proc. natn. Acad. Sci. U.S.A. 78, 3328–3332 (1981).

  17. 17.

    et al. Nature 292, 506–511 (1981).

  18. 18.

    & Cell (in the press).

  19. 19.

    , , & Nature 296, 404–409 (1982).

  20. 20.

    , , , & Proc. natn. Acad. Sci. U.S.A. (in the press).

  21. 21.

    et al. J. Virol. 36, 408–420 (1980).

  22. 22.

    , , & Cell (in the press).

  23. 23.

    , , & Virology 96, 64–79 (1979).

  24. 24.

    , , & Cell 19, 1005–1014 (1980).

  25. 25.

    Nature 204, 1104–1105 (1964).

  26. 26.

    , , & Nature 297, 479–483 (1982).

  27. 27.

    , , & Cancer Res. 26, 1759–1768 (1966).

  28. 28.

    , , & J. Virol. 36, 575–585 (1980).

  29. 29.

    , , , & J. Virol. 34, 200–212 (1980).

  30. 30.

    , , , & Proc. natn. Acad. Sci. U.S.A. (in the press).

  31. 31.

    , , & J. Virol. 39, 625–631 (1981).

  32. 32.

    , , , & J. Virol. 36, 50–61 (1980).

  33. 33.

    , , & Virology 65, 329–409 (1975).

  34. 34.

    et al. J. natn. Cancer Inst. 51, 1417–1421 (1973).

  35. 35.

    et al. Cancer Res. 36, 4562–4569 (1976).

  36. 36.

    , & Nature 270, 347–349 (1977).

  37. 37.

    et al. Nature 249, 224–226 (1974).

  38. 38.

    & J. natn. Cancer Inst. 62, 1017–1021 (1979).

  39. 39.

    , , & J. molec. Biol. 13, 237–251 (1977).

  40. 40.

    , & Cell 25, 23–36 (1981).

  41. 41.

    , & Proc. natn. Acad. Sci. U.S.A. 76, 3683–3687 (1979).

  42. 42.

    , , , & Proc. natn. Acad. Sci. U.S.A. 77, 3855–3859 (1980).

Download references

Author information

Affiliations

  1. Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA

    • Luis F. Parada
    • , Clifford J. Tabin
    • , Chiaho Shih
    •  & Robert A. Weinberg

Authors

  1. Search for Luis F. Parada in:

  2. Search for Clifford J. Tabin in:

  3. Search for Chiaho Shih in:

  4. Search for Robert A. Weinberg in:

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/297474a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.