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Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene

Nature volume 297, pages 474–478 (1982)Cite this article

Abstract

Examination of homologies between retroviral oncogenes and transforming sequences defined by transfection reveals that the human bladder carcinoma (EJ) oncogene is homologous to the Harvey sarcoma virus oncogene (ras). Structural analysis limits the region of homology to a 3.0-kilobase SacI fragment of the EJ oncogene. Both EJ and ras DNA probes detect similar transcripts in transfectants derived from bladder carcinoma cell lines.

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Authors and Affiliations

  1. Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Luis F. Parada, Clifford J. Tabin, Chiaho Shih & Robert A. Weinberg

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  1. Luis F. Parada
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  2. Clifford J. Tabin
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  3. Chiaho Shih
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  4. Robert A. Weinberg
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Parada, L., Tabin, C., Shih, C. et al. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature 297, 474–478 (1982). https://doi.org/10.1038/297474a0

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