Letter | Published:

Interferon inhibits the suppressor T cell response of delayed-type hypersensitivity

Nature volume 296, pages 757759 (22 April 1982) | Download Citation

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Abstract

We have recently shown that pretreatment of BALB/c mice with Corynebacterium parvum preferentially inhibits suppressor T lymphocytes (Ts) which have been induced by an epicutaneous antigen overload1 or by intravenous (i.v.) injection of 2,4-dinitrobenzenesulphonic acid (DNBSO3)2. Serum obtained 24 h after C. parvum injection had a similar suppressive effect on Ts but no effect on T effector lymphocytes of delayed-type hypersensitivity (TDH)3 Inhibition of Ts by this serum could be neutralized by an anti-interferon globulin4. A crude mouse fibroblast interferon (IFN) preparation also inhibited the Ts response4, which suggested that IFN in C. parvum serum might be the Ts inhibitory factor. We have now studied the effect of an electrophoretically purified mouse interferon (IFN-α and β) preparation on the Ts response to dinitrofluorobenzene (DNFB) in BALB/c mice. Small amounts (1,000 U) of the preparation inhibited the generation of Ts by DNBSO3 in vivo, and the function of Ts both in the recipient animals when injected i.v. 2 h after transfer of the Ts and after incubation of the spleen ceUs from tolerant animals with interferon before transfer into recipients. The TDH response was not affected by this amount of interferon.

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Author information

Affiliations

  1. Hautklinik der Universität Münster, von-Esmarch-Strasse 56, D-4400 Münster, FRG

    • J. Knop
    • , R. Stremmer
    • , C. Neumann
    •  & E. Macher
  2. Institut Curie, Section de Biologie, Centre Universitaire, F-91405 Orsay, France

    • E. De Maeyer

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DOI

https://doi.org/10.1038/296757a0

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