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Control of cyclic nucleotide metabolism by non-cholinergic, non-adrenergic nerves in rat thyroid gland

Nature volume 296, pages 751–754 (1982)Cite this article

Abstract

In addition to the well-established role of thyrotropin (TSH) in controlling metabolism and secretion of thyroid follicular cells1–3, there is evidence to suggest nervous (cholinergic and adrenergic) control mechanisms4–8. Nerves showing immunoreactivity to vasoactive intestinal peptide (VIP) have recently been demonstrated in the thyroid gland9, while exogenous VIP has been shown to elevate tissue cyclic AMP levels, increase the number of colloid droplets in follicular cells and increase thyroid hormone secretion in vivo. It was therefore suggested that VIP-containing nerves might control thyroid activity9, although a functional non-cholinergic, non-adrenergic innervation of the thyroid has not yet been demonstrated. By adopting the technique of electrical field stimulation previously used on isolated pancreatic segments10–13, we have studied cyclic nucleotide metabolism in isolated thyroid fragments and have now demonstrated directly the influence of both cholinergic and adrenergic as well as non-cholinergic, non-adrenergic nerves on thyroid cyclic AMP and cyclic GMP metabolism. In the presence of complete cholinergic and adrenergic blockade, nerve stimulation evoked complex time course changes in tissue cyclic AMP and cyclic GMP levels which could be mimicked precisely by VIP. Electrical stimulation of intrinsic thyroid nerves released, in addition to acetylcholine (ACh) and noradrenaline, a transmitter with the same action on thyroid cyclic nucleotide metabolism as VIP.

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References

  1. Dumont, J. E. Vitam. Horm. 29, 287–412 (1971).

    Article  CAS  Google Scholar 

  2. Tong, W. in Handbook of Physiology Vol. 3, Sect. 7 (eds Greer, M. A. & Solomon, D. H.) 255–283 (American Physiological Society, Washington DC, 1974).

    Google Scholar 

  3. Field, J. B. in The Thyroid 4th edn (eds Werner, S. C. & Ingbar, S. H.) 185–195 (Harper & Row, New York, 1978).

    Google Scholar 

  4. Söderberg, U. Acta physiol. scand. 42, Suppl. 147, 1–113 (1958).

    Article  Google Scholar 

  5. Melander, A. in The Thyroid 4th edn (eds Werner, S. C. & Ingbar, S. H.) 216–222 (Harper & Row, New York, 1978).

    Google Scholar 

  6. Dumont, J. E. et al. Adv. Cyclic Nucleotide Res. 9, 723–734 (1978).

    CAS  PubMed  Google Scholar 

  7. Melander, A., Sundler, F. & Westgren, U. Endocrinology 96, 102–106 (1975).

    Article  CAS  Google Scholar 

  8. Melander, A. & Sundler, F. Endocrinology 105, 7–9 (1979).

    Article  CAS  Google Scholar 

  9. Ahrens, B. et al. Nature 287, 343–345 (1980).

    Article  ADS  Google Scholar 

  10. Davison, J. S., Pearson, G. T. & Petersen, O. H. J. Physiol., Lond. 301, 295–305 (1980).

    Article  CAS  Google Scholar 

  11. Nishiyama, A., Kato, K., Saitoh, S. & Wakui, M. Membrane Biochem. 3, 49–66 (1980).

    Article  CAS  Google Scholar 

  12. Pearson, G. T., Davison, J. S., Collins, R. C. & Petersen, O. H. Nature 290, 259–261 (1981).

    Article  ADS  CAS  Google Scholar 

  13. Pearson, G. T., Singh, J., Daoud, M. S., Davison, J. S. & Petersen, O. H. J. biol. Chem. 256, 11025–11031 (1981).

    CAS  PubMed  Google Scholar 

  14. Fenn, W. O. Physiol. Rev. 20, 377–415 (1940).

    Article  CAS  Google Scholar 

  15. Schramm, M. Biochim. biophys. Acta 165, 546–549 (1968).

    Article  CAS  Google Scholar 

  16. Douglas, W. W. Br. J. Pharmac. 34, 451–474 (1968).

    Article  CAS  Google Scholar 

  17. Green, S. T. & Petersen, O. H. Pflügers Arch. ges. Physiol. 391, 119–124 (1981).

    Article  CAS  Google Scholar 

  18. Green, S. T., Singh, J. & Petersen, O. H. Biochim. biophys. Acta 720, 36–41 (1982).

    Article  CAS  Google Scholar 

  19. Narahashi, T. Physiol. Rev. 54, 813–889 (1974).

    Article  CAS  Google Scholar 

  20. Flitney, F. W. & Singh, J. J. Physiol., Lond. 304, 21–42 (1980).

    Article  CAS  Google Scholar 

  21. Gornall, A. G., Bardawill, C. J. & David, M. B. J. biol. Chem. 177, 751–766 (1949).

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Physiology, University of Dundee, Dundee, DD1 4HN, UK

    S. T. Green

  2. The Physiological Laboratory, University of Liverpool, PO Box 147, Liverpool, L69 3BX, UK

    J. Singh & O. H. Petersen

Authors
  1. S. T. Green
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  2. J. Singh
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  3. O. H. Petersen
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Green, S., Singh, J. & Petersen, O. Control of cyclic nucleotide metabolism by non-cholinergic, non-adrenergic nerves in rat thyroid gland. Nature 296, 751–754 (1982). https://doi.org/10.1038/296751a0

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