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Parental exposure to X rays and chemicals induces heritable tumours and anomalies in mice.

Abstract

Although radiation and various chemicals are known to produce mutations, there is a paucity of information on the production of germ-line mutations leading to heritable tumours and anomalies. I now report a significant and large increase in such tumours and anomalies following treatment of ICR parent mice with X rays and urethane. About 90% of the induced tumours were in the lung, and were inherited as if they were dominant mutations with about 40% penetrance.

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Nomura, T. Parental exposure to X rays and chemicals induces heritable tumours and anomalies in mice.. Nature 296, 575–577 (1982). https://doi.org/10.1038/296575a0

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