Letter | Published:

Specific non-opiate binding sites for human β-endorphin on the terminal complex of human complement

Nature volume 296, pages 572574 (08 April 1982) | Download Citation

Subjects

Abstract

The opioid peptide β-endorphin is released from the pituitary into the blood under physical or emotional stress; its target tissues, however, are unknown1. We report here the specific binding of human β-endorphin to both terminal complexes of human complement: the cytolytic, membrane-derived C5b–9(m) complex and the cytolytically inactive, serum-derived SC5b–9 complex. Binding is through the carboxy-terminus of β-endorphin rather than the amino-terminus, which is implicated in binding to opiate receptors. It is conceivable that the binding of β-endorphin to complement has physiological relevance in the adaptation of the immune system to stress.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , & Neurosci. Biobehav. Rev. 4, 77–86 (1980).

  2. 2.

    & J. exp. Med. 141, 724–735 (1975).

  3. 3.

    & J. Immun. 127, 576–602 (1981).

  4. 4.

    , , , & Scand. J. Immun. 7, 45–56 (1978).

  5. 5.

    , & Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 303, 171–174 (1978).

  6. 6.

    , & Biochem. biophys. Res. Commun. 77, 361–366 (1977).

  7. 7.

    & Proc. natn. Acad. Sci. U.S.A. 78, 1818–1822 (1981).

  8. 8.

    & Proc. natn. Acad. Sci. U.S.A. 77, 5972–5974 (1980).

  9. 9.

    , , & Science 208, 183–185 (1980).

  10. 10.

    & Molec. Pharmac. 10, 837–848 (1974).

  11. 11.

    , & Pharmacology 14, 322–329 (1976).

  12. 12.

    Histochemistry 69, 157–160 (1980).

  13. 13.

    , , & Biochem. Pharmac. 29, 1361–1365 (1980).

  14. 14.

    et al. J. Immun. 125, 2539–2543 (1980).

  15. 15.

    , , & J. Immun. 123, 1068–1070 (1979).

  16. 16.

    , & Science 205, 1033–1035 (1979).

  17. 17.

    , & Life Sci. 28, 1637–1640 (1981).

  18. 18.

    et al. Experientia 36, 987–989 (1980).

  19. 19.

    , , , & in Endogenous and Exogenous Opiate Agonists and Antagonists (ed. Way, E. L.) 307–308 (Pergamon, New York, 1980).

  20. 20.

    , , & Life Sci. 24, 1659–1666 (1979).

  21. 21.

    et al. Life Sci. 25, 835–844 (1979).

  22. 22.

    , Scand. J. Immun. Suppl. 1 69–70 (1973).

  23. 23.

    & Outlines of Receptor Theory (Elsevier, Amsterdam, 1980).

Download references

Author information

Affiliations

  1. Rudolf Buchheim-Institut für Pharmakologie, Liebig-Universität Gieβen, Frankfurter Strasse 107, D-6300 Gieβen, FRG

    • L. Schweigerer
    •  & H. Teschemacher
  2. Institut für Medizinische Mikrobiologie der Justus, Liebig-Universität Gieβen, Frankfurter Strasse 107, D-6300 Gieβen, FRG

    • S. Bhakdi

Authors

  1. Search for L. Schweigerer in:

  2. Search for S. Bhakdi in:

  3. Search for H. Teschemacher in:

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/296572a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.