Abstract
We have sequenced secreted and membrane terminal exons of the murine immunoglobulin δ chain. The putative transmembranal exon is strikingly similar to that of the μ chain and the internal cytoplasmic exon codes for exactly the same two amino acids, valine and lysine. A third potential exon was found between S and M exons that could code for yet another hydrophilic carboxyl terminus termed δX.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Warner, N. L., Byrt, P. & Ada, G. L. Nature 226, 942–943 (1970).
Davie, T. M. & Paul, W. E. (1972) J. exp. Med. 134, 495–516 (1972).
Coffman, R. L. & Cohn, M. J. Immun. 118, 1806–1815 (1977).
Cosenza, H. & Köhler, H. Proc. natn. Acad. Sci. U.S.A. 69, 2701–2705 (1972).
Eichman, K. & Rajewsky, K. Eur. J. Immun. 5, 661–666 (1975).
Vitetta, E. S. & Uhr, J. W. Immun. Rev. 37, 50–58 (1977).
Bargellesi, A., Corte, G., Cosulich, E. E. & Ferrarini, M. Eur. J. Immun. 9, 490–492 (1979).
Finkelman, F. D., Woods, V. L., Berning, A. & Scher, I. J. Immun. 123, 1253–1259 (1979).
Vitetta, E. S. & Uhr, J. W. Science 189, 964–969 (1975).
Sidman, C. L. & Unanue, E. R. Proc. natn. Acad. Sci. U.S.A. 75, 2401–2405 (1978).
Vitetta, E. S. & Uhr, J. W. J. Immun. 117, 1579–1583 (1976).
Bourgois, A., Abney, E. R. & Parkhouse, R. M. E. Eur. J. Immun. 7, 210–213 (1977).
Coutinho, A. & Moller, G. Scand. J. Immun. 4, 99–102 (1975).
Pure, E. & Vitetta, E. S. J. Immun. 125, 420–427 (1980).
Jacobson, E. B. et al. J. exp. Med. 154, 318–332 (1981).
Layton, J. E., Johnson, G. R., Scott, D. W. & Nossal, G. J. V. Eur. J. Immun. 8, 325–330 (1978).
Rogers, J. et al. Cell 20, 303–312 (1980).
Early, P. et al. Cell 20, 313–319 (1980).
Yuan, D., Uhr, J. W. & Vitetta, E. S. J. Immun. 125, 40–46 (1980).
Kehry, M., Sibley, C., Fuhrman, C., Schilling, J. & Hood, L. Proc. natn. Acad. Sci. U.S.A. 76, 2932–2936 (1979).
Tucker, P. W., Liu, C. P., Mushinski, J. F. & Blattner, F. R. Science 209, 1353–1360 (1980).
Dildrop, R. & Beyreuther, K. Nature 292, 61–63 (1981).
Tucker, P. W. et al. in B, Lymphocytes in the Immune Response Vol. 15 (eds Klenman, N., Mosier, D. E., Scher, I. & Vitetta, E. S.) 43 (Elsevier, Amsterdam, 1981).
Moore, K. W. et al. Proc. natn. Acad. Sci. U.S.A. 78, 1800–1804 (1981).
Fitzmaurice, L. et al. in Immunoglobulins Idiotypes and Their Expression (eds Juneway, C, Sercarz, E. E., Wigzell, H. & Fox, C. F.) 263–269 (Academic, New York, 1981).
Maki, R. et al. Cell 24, 353–365 (1981).
Fitzmaurice, L. et al. Nature 296, 459–462 (1982).
Liu, C. P., Tucker, P. W., Mushinski, J. F. & Blattner, F. R. Science 209, 1348–1353 (1980).
Maxam, A. M. & Gilbert, W. Meth. Enzym. 65, 499–560 (1980).
Thomas, P. Proc. natn. Acad. Sci. U.S.A. 77, 5201–5205 (1980).
Alwine, J. C., Kemp, D. J. & Stark, G. R. Proc. natn. Acad. Sci. U.S.A. 74, 5350–5354 (1977).
Tucker, P. W., Slightom, J. & Blattner, F. R. Proc. natn. Acad. Sci. U.S.A. 78, 7684–7688 (1981).
Proudfoot, N. J. & Brownlee, G. G. Nature 252, 359–362 (1974).
Jung, A., Sippel, A. E., Grez, M. & Schutz, G. Proc. natn. Acad. Sci. U.S.A. 77, 5759–5763 (1980).
Hagenbuchle, O., Bovey, R. & Young, R. A. Cell 21, 179–187 (1980).
Mushinski, J. F. et al. Proc. natn. Acad. Sci. U.S.A. 77, 7405–7409 (1980).
Lin, L. C. & Putnam, F. Proc. natn. Acad. Sci. U.S.A. 76, 6572–6576 (1979).
Tucker, P. W., Robinson, R., Cheng, H-L. & Blattner, F. R. J. supramolec. Struct. Suppl. 5, 14 (1981).
Eidels, L. J. Immun. 123, 891–902 (1979).
Mescher, M. & Pollock, R. R. J. Immun. 123, 1155–1161 (1979).
McCune, J. M., Fu, S. M., Kunkel, H. C. & Blobel, G. Proc. natn. Acad. Sci. U.S.A. 78, 5127–5131 (1981).
Setzer, D. R., McGrogan, M., Nunberg, J. H. & Schimke, R. T. Cell 22, 361–370 (1980).
Ziff, E. B. Nature 287, 491–499 (1980).
Blattner, F. R. et al. Proc. N.Y. Acad. Sci. (in the press).
Honjo, T. & Kataoka, T. Proc. natn. Acad. Sci. U.S.A. 75, 21–40 (1978).
Janeway, C. A. Jr, Murgita, R. A., Weinbaum, F. I., Asofsky, R. & Wigzell, H. Proc. natn. Acad. Sci. U.S.A. 74, 4582–4586 (1977).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cheng, HL., Blattner, F., Fitzmaurice, L. et al. Structure of genes for membrane and secreted murine IgD heavy chains. Nature 296, 410–415 (1982). https://doi.org/10.1038/296410a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/296410a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.