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Structure of genes for membrane and secreted murine IgD heavy chains

Nature volume 296, pages 410415 (01 April 1982) | Download Citation

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Abstract

We have sequenced secreted and membrane terminal exons of the murine immunoglobulin δ chain. The putative transmembranal exon is strikingly similar to that of the μ chain and the internal cytoplasmic exon codes for exactly the same two amino acids, valine and lysine. A third potential exon was found between S and M exons that could code for yet another hydrophilic carboxyl terminus termed δX.

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Author information

Affiliations

  1. University of Texas Southwestern Medical School, Department of Microbiology, Dallas, Texas 75235, USA

    • Hwei-Ling Cheng
    •  & Philip W. Tucker
  2. University of Wisconsin, Department of Genetics, Madison, Wisconsin 53706, USA

    • Frederick R. Blattner
  3. Laboratory Immunology (NIAID), National Institutes of Health, Bethesda, Maryland 20205, USA

    • Leona Fitzmaurice
  4. Laboratory of Cell Biology (NCI), National Institutes of Health, Bethesda, Maryland 20205, USA

    • J. Frederic Mushinski

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https://doi.org/10.1038/296410a0

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